Evidence map›Paper›PMID 28566515›Full record

ArticleJournal of the Royal Society, Interface2017

A microfluidics assay to study invasion of human placental trophoblast cells.

Yassen Abbas, Carolin Melati Oefner, William J Polacheck, Lucy Gardner, Lydia Farrell, Andrew Sharkey, Roger Kamm, Ashley Moffett, Michelle L Oyen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Current approaches and advances in placental toxicology.Trends in endocrinology and metabolism: TEM · 2026
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Frontiers in immunology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Yassen AbbasThe Nanoscience Centre, Department of Engineering, University of Cambridge, Cambridge CB3 0FF, UK.
Carolin Melati OefnerThe Nanoscience Centre, Department of Engineering, University of Cambridge, Cambridge CB3 0FF, UK.
William J PolacheckDepartment of Mechanical Engineering, Cambridge, MA 02139, USA.
Lucy GardnerDepartment of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.
Lydia FarrellDepartment of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.
Andrew SharkeyDepartment of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.
Roger KammDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Ashley MoffettDepartment of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.
Michelle L OyenThe Nanoscience Centre, Department of Engineering, University of Cambridge, Cambridge CB3 0FF, UK mlo29@cam.ac.uk.ORCID 0000-0002-3428-748X
University of Cambridge · GBMassachusetts Institute of Technology · US

Funding

Modulation of vascular permeability by shear stress via Notch signalingF32HL129733 · NHLBI · HARVARD UNIVERSITY · PI POLACHECK, WILLIAM J · 2016 to 2017
$108k
British Heart Foundation PG/09/077/27964Medical Research Council MR/P001092/1NHLBI NIH HHS F32 HL129733Wellcome Trust
6 · The paper itself

Abstract

Pre-eclampsia, fetal growth restriction and stillbirth are major pregnancy disorders throughout the world. The underlying pathogenesis of these diseases is defective placentation characterized by inadequate invasion of extravillous placental trophoblast cells into the uterine arteries. How trophoblast invasion is controlled remains an unanswered question but is influenced by maternal uterine immune cells called decidual natural killer cells. Here, we describe an

Indexed as

MicrofluidicsModels, BiologicalCell MovementComputer SimulationFemaleGene Expression RegulationGranulocyte-Macrophage Colony-Stimulating FactorHumansPlacentaPregnancyReceptors, KIRTrophoblastsGranulocyte-Macrophage Colony-Stimulating FactorKIR2DS1 protein, humanReceptors, KIRhumanmicrofluidicsplacentationtrophoblast

Identifiers

PMID28566515
PMCPMC5454302
OpenAlexW2619407701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.