Evidence map›Paper›PMID 28566498›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Thermal combination therapies for local drug delivery by magnetic resonance-guided high-intensity focused ultrasound.

Nicole Hijnen, Esther Kneepkens, Mariska de Smet, Sander Langereis, Edwin Heijman, Holger Grüll

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 96 citations in OpenAlex.

  1. Ultrasound-responsive composite hydrogels: Design rules for spatiotemporally controlled drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Focused Ultrasound for Sarcomas: A Narrative Review.Current oncology (Toronto, Ont.) · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nicole HijnenDepartment of Biomedical Engineering, Biomedical NMR, Eindhoven University of Technology, Eindhoven, 5600 MB Eindhoven, The Netherlands.
Esther KneepkensDepartment of Biomedical Engineering, Biomedical NMR, Eindhoven University of Technology, Eindhoven, 5600 MB Eindhoven, The Netherlands.
Mariska de SmetDepartment of Biomedical Engineering, Biomedical NMR, Eindhoven University of Technology, Eindhoven, 5600 MB Eindhoven, The Netherlands.
Sander LangereisDepartment of Oncology Solutions, Philips Research Eindhoven, 5656 AE Eindhoven, The Netherlands.
Edwin HeijmanDepartment of Oncology Solutions, Philips Research Eindhoven, 5656 AE Eindhoven, The Netherlands.
Holger GrüllDepartment of Biomedical Engineering, Biomedical NMR, Eindhoven University of Technology, Eindhoven, 5600 MB Eindhoven, The Netherlands; holger.gruell@uk-koeln.de.
Eindhoven University of Technology · NLPhilips (Netherlands) · NLUniversity Hospital Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several thermal-therapy strategies such as thermal ablation, hyperthermia-triggered drug delivery from temperature-sensitive liposomes (TSLs), and combinations of the above were investigated in a rhabdomyosarcoma rat tumor model (

Indexed as

AnimalsAntibiotics, AntineoplasticCell Line, TumorCombined Modality TherapyDoxorubicinDrug Delivery SystemsFemaleHigh-Intensity Focused Ultrasound AblationHyperthermia, InducedIndium RadioisotopesLiposomesMagnetic Resonance ImagingPolyethylene GlycolsRatsRhabdomyosarcomaTemperatureAntibiotics, AntineoplasticDoxorubicinIndium Radioisotopesliposomal doxorubicinLiposomesPolyethylene Glycolsablationdrug deliveryfocused ultrasoundhyperthermiatemperature-sensitive liposomes

Identifiers

PMID28566498
PMCPMC5474813
OpenAlexW2618296973

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.