Evidence map›Paper›PMID 28566469›Full record

ArticleClinical science (London, England : 1979)2017

Visceral adipose tissue activated macrophage content and inflammatory adipokine secretion is higher in pre-eclampsia than in healthy pregnancys.

Shahzya S Huda, Fiona Jordan, Jack Bray, Gillian Love, Reba Payne, Naveed Sattar, Dilys J Freeman

Open access · hybridAbstract read
In one paragraph

Article in Clinical science (London, England : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Emerging Role of Leptin in Vascular and Placental Dysfunction in Preeclampsia.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
  4. Position Statement on Cardiometabolic Health Across the Woman's Life Course - 2025.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Markers of inflammation in obese pregnant women: Adenosine deaminase and high sensitive C - reactive protein.European journal of obstetrics & gynecology and reproductive biology: X · 2022
    Article
  10. Review
  11. Article
  12. Adipokine profiles in preeclampsia.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2020
    Article
  13. Review
  14. Molecular Links between Central Obesity and Breast Cancer.International journal of molecular sciences · 2019
    Review
  15. Dyslipidemia and the role of adipose tissue in early pregnancy in the BPH/5 mouse model for preeclampsia.American journal of physiology. Regulatory, integrative and comparative physiology · 2019
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shahzya S HudaWomen and Childrens, Forth Valley Royal Hospital, Larbert, U.K. Shahzya.huda@nhs.net.
Fiona JordanInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
Jack BraySchool of Medicine, University of Glasgow, Glasgow, U.K.
Gillian LoveInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
Reba PayneInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
Naveed SattarInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
Dilys J FreemanInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
University of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity increases pre-eclampsia (PE) risk. Adipose tissue inflammation may contribute to the clinical syndrome of PE. We compared adipose tissue macrophage infiltration and release of pro-inflammatory adipokines in PE and healthy pregnancy. Subcutaneous and visceral adipose tissue biopsies were collected from healthy (

Indexed as

AdipocytesAdipokinesAdultBody Mass IndexCase-Control StudiesChemokine CCL2C-Reactive ProteinFemaleGene ExpressionHumansInflammationInflammation MediatorsInterleukin-1 Receptor-Like 1 ProteinInterleukin-6Intra-Abdominal FatMacrophage ActivationAdipokinesCCL2 protein, humanChemokine CCL2C-Reactive ProteinIL1RL1 protein, humanInflammation MediatorsInterleukin-1 Receptor-Like 1 ProteinInterleukin-6RNA, MessengerTumor Necrosis Factor-alphaadipocytesadipokinespreeclampsiapregnancy

Identifiers

PMID28566469
PMCPMC6376613
OpenAlexW2618569794

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.