ArticleJournal of neurophysiology2017
Activation of ganglion cells and axon bundles using epiretinal electrical stimulation.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 83 citations in OpenAlex.
- Leveraging current steering and the biophysics of spike generation for cellular-resolution electrical stimulation of neurons.Cell reports · 2026Article
- Restoration of Sight with Electronic Retinal Prostheses.Annual review of vision science · 2025Review
- Direct-Print 3D Electrodes for Large-Scale, High-Density, and Customizable Neural Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Engineered biological neuronal networks as basic logic operators.Frontiers in computational neuroscience · 2025Article
- Electrical excitability of neuronal networks based on the voltage threshold of electrical stimulation.Scientific reports · 2024Article
- Article
- Spike sorting in the presence of stimulation artifacts: a dynamical control systems approach.Journal of neural engineering · 2024Article
- Comparison of modulation efficiency between normal and degenerated primate retina.Frontiers in cell and developmental biology · 2024Article
- Multiple consecutive-biphasic pulse stimulation improves spatially localized firing of retinal ganglion cells in the degenerate retina.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023Article
- Inferring light responses of primate retinal ganglion cells using intrinsic electrical signatures.Journal of neural engineering · 2023Article
- Electronic Retinal Prostheses.Cold Spring Harbor perspectives in medicine · 2023Review
- Inference of Electrical Stimulation Sensitivity from Recorded Activity of Primate Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Retinal Prostheses: Engineering and Clinical Perspectives for Vision Restoration.Sensors (Basel, Switzerland) · 2023Review
- High-Fidelity Reproduction of Visual Signals by Electrical Stimulation in the Central Primate Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Focal electrical stimulation of human retinal ganglion cells for vision restoration.Journal of neural engineering · 2022Article
- Correlated Activity in the Degenerate Retina Inhibits Focal Response to Electrical Stimulation.Frontiers in cellular neuroscience · 2022Article
- Morphological Factors that Underlie Neural Sensitivity to Stimulation in the Retina.Advanced nanobiomed research · 2021Article
- Spatially patterned bi-electrode epiretinal stimulation for axon avoidance at cellular resolution.Journal of neural engineering · 2021Article
- Automatic Identification of Axon Bundle Activation for Epiretinal Prosthesis.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2021Article
- Block Phenomena During Electric Micro-Stimulation of Pyramidal Cells and Retinal Ganglion Cells.Frontiers in cellular neuroscience · 2021Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Epiretinal prostheses for treating blindness activate axon bundles, causing large, arc-shaped visual percepts that limit the quality of artificial vision. Improving the function of epiretinal prostheses therefore requires understanding and avoiding axon bundle activation. This study introduces a method to detect axon bundle activation on the basis of its electrical signature and uses the method to test whether epiretinal stimulation can directly elicit spikes in individual retinal ganglion cells without activating nearby axon bundles. Combined electrical stimulation and recording from isolated primate retina were performed using a custom multielectrode system (512 electrodes, 10-μm diameter, 60-μm pitch). Axon bundle signals were identified by their bidirectional propagation, speed, and increasing amplitude as a function of stimulation current. The threshold for bundle activation varied across electrodes and retinas, and was in the same range as the threshold for activating retinal ganglion cells near their somas. In the peripheral retina, 45% of electrodes that activated individual ganglion cells (17% of all electrodes) did so without activating bundles. This permitted selective activation of 21% of recorded ganglion cells (7% of expected ganglion cells) over the array. In one recording in the central retina, 75% of electrodes that activated individual ganglion cells (16% of all electrodes) did so without activating bundles. The ability to selectively activate a subset of retinal ganglion cells without axon bundles suggests a possible novel architecture for future epiretinal prostheses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.