ArticleJournal of virology2017
Critical Role for Monocytes/Macrophages in Rapid Progression to AIDS in Pediatric Simian Immunodeficiency Virus-Infected Rhesus Macaques.
Erratum issuedOpen access · bronzeAbstract readComparative Study
In one paragraph
Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- SIV infection induces aging-like alterations in cardiac cellularity and macrophage populations of rhesus macaques.Journal of leukocyte biology · 2026Article
- Monocytes across life span in HIV infection: lights and shadows.Current opinion in HIV and AIDS · 2025Review
- Immune perturbation following SHIV infection is greater in newborn macaques than in infants.JCI insight · 2024Article
- Review
- More than the Infinite Monkey Theorem: NHP Models in the Development of a Pediatric HIV Cure.Current HIV/AIDS reports · 2024Review
- Independent actions by HIV-1 Tat and morphine to increase recruitment of monocyte-derived macrophages into the brain in a region-specific manner.Neuroscience letters · 2022Article
- HIV-1 cure strategies: why CRISPR?Expert opinion on biological therapy · 2021Review
- Neurocognitive Complications of Pediatric HIV Infections.Current topics in behavioral neurosciences · 2021Article
- Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques.Journal of virology · 2020Article
- The Brain Retains: Nonhuman Primate Models for Pediatric HIV-1 in the CNS.Current HIV/AIDS reports · 2020Review
- Lack of susceptibility in neonatally infected rhesus macaques to simian immunodeficiency virus-induced encephalitis.Journal of neurovirology · 2019Article
- Shifting Dynamics of Intestinal Macrophages during Simian Immunodeficiency Virus Infection in Adult Rhesus Macaques.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- High Plasma Soluble CD163 During Infancy Is a Marker for Neurocognitive Outcomes in Early-Treated HIV-Infected Children.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Current and Future Therapeutic Strategies for Lentiviral Eradication from Macrophage Reservoirs.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019Review
- High Turnover of Tissue Macrophages Contributes to Tuberculosis Reactivation in Simian Immunodeficiency Virus-Infected Rhesus Macaques.The Journal of infectious diseases · 2018Article
- Visualizing the Immune System: Providing Key Insights into HIV/SIV Infections.Frontiers in immunology · 2018Review
- Role of Monocyte/Macrophages during HIV/SIV Infection in Adult and Pediatric Acquired Immune Deficiency Syndrome.Frontiers in immunology · 2017Review
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 4 institutions in 2 countries.
Chie SugimotoDivision of Immunology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Kristen M MerinoDivision of Immunology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Atsuhiko HasegawaDivision of Immunology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Xiaolei WangDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Xavier A AlvarezDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Hiroshi WakaoDepartment of Hygiene and Cellular Preventive Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Kazuyasu MoriAIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.ORCID http://orcid.org/0000-0002-1841-6376
Woong-Ki KimDepartment of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, USA.
Ronald S VeazeyDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Elizabeth S DidierDivision of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Marcelo J KurodaDivision of Immunology, Tulane National Primate Research Center, Covington, Louisiana, USA mkuroda@tulane.edu.
Tulane University · USEastern Virginia Medical School · USHokkaido University · JPNational Institute of Infectious Diseases · JP
Funding
National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5MTulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4MMacrophages in the pathogenesis of AIDSR01AI097059 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KURODA, MARCELO J · 2012 to 2016
$4.0MRole of Macrophages in Lung Disease Pathogenesis of Pediatric AIDSR01HL125054 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KURODA, MARCELO J, VEAZEY, RONALD S. · 2014 to 2017
$3.3MTargeting HIV Lung Reservoir in the Macaque ModelR33AI110163 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KURODA, MARCELO J · 2016 to 2018
$1.5MLeica TCS SP8 Confocal Microscope SystemS10OD019964 · OD · TULANE UNIVERSITY OF LOUISIANA · PI LACKNER, ANDREW A · 2015 to 2015
$478kTargeting Macrophage Reservoirs in the Macaque Model of Pediatric AIDSR21AI116198 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KURODA, MARCELO J · 2014 to 2015
$465kMonocyte/macrophages in Pediatric AIDSR21AI091501 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KURODA, MARCELO J · 2010 to 2011
$451kTargeting Brain Macrophage Reservoirs of Infection in Pediatric NeuroAIDSR21MH108458 · NIMH · EASTERN VIRGINIA MEDICAL SCHOOL · PI KIM, WOONG-KI · 2015 to 2016
$442kNHLBI NIH HHS R01 HL125054NIAID NIH HHS R01 AI097059NIAID NIH HHS R21 AI091501NIAID NIH HHS R21 AI116198NIAID NIH HHS R33 AI110163NIH HHS P51 OD011104NIH HHS P51 OD011107NIH HHS S10 OD019964NIMH NIH HHS R21 MH108458
Abstract
Infant humans and rhesus macaques infected with the human or simian immunodeficiency virus (HIV or SIV), respectively, express higher viral loads and progress more rapidly to AIDS than infected adults. Activated memory CD4
Indexed as
AnimalsCD4-Positive T-LymphocytesDisease Models, AnimalDisease ProgressionHIV InfectionsHumansMacaca mulattaMacrophagesMonocytesRNA, ViralSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusViral LoadRNA, ViralAIDSmacrophagespediatric infectious diseasesimian immunodeficiency virus
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.