Evidence map›Paper›PMID 28566335›Full record

ArticleClinical and vaccine immunology : CVI2017

Breadth and Duration of Meningococcal Serum Bactericidal Activity in Health Care Workers and Microbiologists Immunized with the MenB-FHbp Vaccine.

Eduardo Lujan, Elizabeth Partridge, Serena Giuntini, Sanjay Ram, Dan M Granoff

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02569632 (Immunogenicity of a U.S.-Licensed Meningococcal Serogroup B Vaccine), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02569632 phase4completednot on this map

Immunogenicity of a U.S.-Licensed Meningococcal Serogroup B Vaccine (Trumenba) in Adults at Increased Risk of Meningococcal Disease Because of Occupational Exposure

TypeinterventionalSponsorUCSF Benioff Children's Hospital OaklandRan2015 to 2016Enrolled18ConditionsMeningococcal InfectionsArmsTrumenba Vaccine (Wyeth/Pfizer Pharmaceuticals)
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Meningococcal Vaccination: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2020
    Guideline
  2. Article
  3. Is meningococcal B vaccination needed in the post-COVID-19 world?Biomedica : revista del Instituto Nacional de Salud · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. A physician's guide to the 2-dose schedule of MenB-FHbp vaccine.Human vaccines & immunotherapeutics · 2019
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Eduardo LujanCenter for Immunobiology and Vaccine Development, UCSF Benioff Children's Hospital Oakland, Oakland, California, USA.
Elizabeth PartridgeCenter for Immunobiology and Vaccine Development, UCSF Benioff Children's Hospital Oakland, Oakland, California, USA.
Serena GiuntiniCenter for Immunobiology and Vaccine Development, UCSF Benioff Children's Hospital Oakland, Oakland, California, USA.
Sanjay RamDivision of Immunology and Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Dan M GranoffCenter for Immunobiology and Vaccine Development, UCSF Benioff Children's Hospital Oakland, Oakland, California, USA dgranoff@chori.org.
University of Massachusetts Chan Medical School · USUCSF Benioff Children's Hospital · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Novel vaccine strategies for prevention of N. meningitidis group B diseaseR01AI046464 · NIAID · OMVAX, INC. · PI MOE, GREGORY ROBERT · 2000 to 2024
$12.1M
The effect of binding of fH to meningococcal fHbp vaccine on antibody protectionR01AI114701 · NIAID · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI BEERNINK, PETER T. · 2015 to 2019
$3.3M
Immune defenses against Neisseria gonorrhoeaeR01AI114790 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RAM, SANJAY, RICE, PETER A. · 2015 to 2019
$3.1M
Vaccines and Immunotherapeutics against gonorrhea in the contex of Chlamydia coU01AI118161 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RAM, SANJAY · 2014 to 2017
$2.0M
CONSTRUCTION OF THE VACCINE CENTERC06RR016226 · NCRR · CHILDREN'S HOSPITAL &RES CTR AT OAKLAND · PI LUCAS, ALEXANDER H. · 2002 to 2002
$2.0M
Sialic acid analogs as novel immunotherapeutics against multidrug-resistant gonorrheaR21AI119327 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GULATI, SUNITA, RAM, SANJAY · 2015 to 2016
$456k
NCATS NIH HHS UL1 TR000004NCRR NIH HHS C06 RR016226NIAID NIH HHS R01 AI046464NIAID NIH HHS R01 AI114701NIAID NIH HHS R01 AI114790NIAID NIH HHS R21 AI119327NIAID NIH HHS U01 AI118161
6 · The paper itself

Abstract

MenB-FHbp is a meningococcal serogroup B vaccine with two factor H binding protein (FHbp) antigens from subfamilies A and B. For licensure, efficacy was inferred from serum bactericidal antibody (SBA) responses to four reference strains. Only limited information is available on the breadth or duration of protective SBA responses to genetically diverse disease-causing strains. Seventeen health care or laboratory workers were immunized with two (

Indexed as

Health PersonnelImmunogenicity, VaccineMedical Laboratory PersonnelAntibodies, BacterialAntigens, BacterialBacterial ProteinsHumansMeningitis, MeningococcalMeningococcal InfectionsMeningococcal VaccinesMicrobiologyNeisseria meningitidis, Serogroup BSerogroupSerum Bactericidal Antibody AssayTime FactorsVaccinationAntibodies, BacterialAntigens, BacterialBacterial Proteinsfactor H-binding protein, Neisseria meningitidisMeningococcal Vaccinesfactor H binding proteinFHbpmeningococcal vaccineNeisseria meningitidisTrumenbavaccines

Identifiers

PMID28566335
PMCPMC5583465
OpenAlexW2618612854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.