Evidence map›Paper›PMID 28566218›Full record

ArticleThe lancet. Diabetes & endocrinology2017

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.

Stephen Zewinger, Marcus E Kleber, Vinicius Tragante, Raymond O McCubrey, Amand F Schmidt, Kenan Direk, Ulrich Laufs, Christian Werner, Wolfgang Koenig, Dietrich Rothenbacher and 95 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The lancet. Diabetes & endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Lipoprotein(a) Does Not Correlate with Hypertensive Mediated Organ Damage and Subsequent Cardiovascular Events in a Primary Prevention Cohort.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
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  6. Article
  7. Article
  8. Article
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  10. Observational
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  12. Article
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  14. Review
  15. Polygenic prediction of human longevity on the supposition of pervasive pleiotropy.medRxiv : the preprint server for health sciences · 2023
    Article
  16. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

105 authors at 20 institutions in 14 countries.

Stephen ZewingerDepartment of Internal Medicine IV, Saarland University Hospital, Homburg/Saar, Germany.
Marcus E KleberFifth Department of Medicine, University Heidelberg, Mannheim, Germany; Institute of Nutrition, Friedrich-Schiller University, Jena, Germany.
Vinicius TraganteDepartment of Cardiology, Heart and Lungs Division, UMC Utrecht, Utrecht, Netherlands.
Raymond O McCubreyIntermountain Heart Institute, Intermountain Medical Center, University of Utah School of Medicine, Salt Lake City, UT, USA.
Amand F SchmidtInstitute of Cardiovascular Science Facultyof Population Health Science, University College London, London, UK.
Kenan DirekInstitute of Cardiovascular Science Facultyof Population Health Science, University College London, London, UK.
Ulrich LaufsDepartment of Internal Medicine III, Saarland University Hospital, Homburg/Saar, Germany.
Christian WernerDepartment of Internal Medicine III, Saarland University Hospital, Homburg/Saar, Germany.
Wolfgang KoenigDepartment of Internal Medicine II-Cardiology, University of Ulm Medical Centre, Ulm, Germany; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; German Centre of Cardiovascular Research (DZHK), Partner site Munich Heart Alliance, Munich, Germany.
Dietrich RothenbacherDivision of Clinical Epidemiology and Ageing Research, German Cancer Centre (DKFZ), Heidelberg, Germany; Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Ute MonsDivision of Clinical Epidemiology and Ageing Research, German Cancer Centre (DKFZ), Heidelberg, Germany.
Lutz P BreitlingDivision of Clinical Epidemiology and Ageing Research, German Cancer Centre (DKFZ), Heidelberg, Germany.
Herrmann BrennerNetwork Ageing Research, University Heidelberg, Mannheim, Germany; Division of Clinical Epidemiology and Ageing Research, German Cancer Centre (DKFZ), Heidelberg, Germany.
Richard T JenningsDepartment of Internal Medicine IV, Saarland University Hospital, Homburg/Saar, Germany.
Ioannis PetrakisDepartment of Internal Medicine IV, Saarland University Hospital, Homburg/Saar, Germany.
Sarah TriemDepartment of Internal Medicine IV, Saarland University Hospital, Homburg/Saar, Germany.
Mira KlugDepartment of Internal Medicine IV, Saarland University Hospital, Homburg/Saar, Germany.
Alexandra FilipsDepartment of Internal Medicine IV, Saarland University Hospital, Homburg/Saar, Germany.
Stefan BlankenbergUniversity Heart Centre Hamburg, Clinic for General and Interventional Cardiology, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK e.V.), partner site Hamburg/Kiel/Lübeck, Germany.
Christoph WaldeyerUniversity Heart Centre Hamburg, Clinic for General and Interventional Cardiology, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK e.V.), partner site Hamburg/Kiel/Lübeck, Germany.
Christoph SinningUniversity Heart Centre Hamburg, Clinic for General and Interventional Cardiology, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK e.V.), partner site Hamburg/Kiel/Lübeck, Germany.
Renate B SchnabelUniversity Heart Centre Hamburg, Clinic for General and Interventional Cardiology, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK e.V.), partner site Hamburg/Kiel/Lübeck, Germany.
Karl J LacknerInstitute of Clinical Chemistry and Laboratory Medicine, University Medical Centre Mainz, Germany.
Efthymia VlachopoulouTransplantation Laboratory, Haartman Institute, University of Helsinki, Finland.
Ottar NygårdDepartment of Clinical Science, University of Bergen, Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Gard Frodahl Tveitevåg SvingenDepartment of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Eva Ringdal PedersenDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Grethe S TellDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Juha SinisaloHeart and Lung Centre, Helsinki University Hospital, Helsinki, Finland.
Markku S NieminenHeart and Lung Centre, Helsinki University Hospital, Helsinki, Finland.
Reijo LaaksonenMedical School, Tampere University, Tampere, Finland; Finnish Clinical Biobank Tampere, University Hospital of Tampere, Tampere, Finland.
Stella TrompetDepartment of Geriatics and Gerontology, Leiden University Medical Centre, Leiden, Netherlands; Department of Cardiology, Leiden University Medical Centre, Leiden, Netherlands.
Roelof A J SmitDepartment of Geriatics and Gerontology, Leiden University Medical Centre, Leiden, Netherlands; Department of Cardiology, Leiden University Medical Centre, Leiden, Netherlands.
Naveed SattarInstitute of Cardiovascular and Medical Science, BHF Glasgow, Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
J Wouter JukemaEinthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, Netherlands.
Heinrich V GroesdonkDepartment of Anesthesiology, Intensive Care Medicine, and Pain Medicine, Saarland University Hospital, Homburg/Saar, Germany.
Graciela DelgadoFifth Department of Medicine, University Heidelberg, Mannheim, Germany.
Tatjana StojakovicClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria.
Anna P PilbrowChristchurch Heart Institute, University of Otago, Christchurch, New Zealand.
Vicky A CameronChristchurch Heart Institute, University of Otago, Christchurch, New Zealand.
A Mark RichardsChristchurch Heart Institute, University of Otago, Christchurch, New Zealand; Cardiovascular Research Institute, National University of Singapore, Singapore.
Robert N DoughtyHeart Health Research Group, University of Auckland, New Zealand.
Yan GongDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, Colleges of Pharmacy, University of Florida, Gainesville, FL, USA.
Rhonda Cooper-DeHoffDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, Colleges of Pharmacy, University of Florida, Gainesville, FL, USA.
Julie JohnsonDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, Colleges of Pharmacy, University of Florida, Gainesville, FL, USA.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany; LIFE Research Centre for Civilisation Diseases, University of Leipzig, Leipzig, Germany.
Frank BeutnerHeart Centre Leipzig, Leipzig, Germany.
Joachim ThieryLIFE Research Centre for Civilisation Diseases, University of Leipzig, Leipzig, Germany; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Leipzig, Germany.
J Gustav SmithDepartment of Cardiology, Clinical Sciences, Lund University, Lund, Sweden; Skåne University Hospital, Lund, Sweden.
Ragnar O VilmundarsonRuddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Ruth McPhersonRuddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Alexandre F R StewartRuddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Sharon CresciDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA; Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
Petra A LenziniStatistical Genomics Division, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
John A SpertusSaint Luke's Mid America Heart Institute, Kansas City, MO, USA; Department of Biomedical and Health Informatics, University of Missouri-Kansas City, Kansas City, MO, USA.
Oliviero OlivieriDepartment of Medicine, University of Verona, Verona, Italy.
Domenico GirelliDepartment of Medicine, University of Verona, Verona, Italy.
Nicola I MartinelliDepartment of Medicine, University of Verona, Verona, Italy.
Andreas LeihererVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria; Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.
Christoph H SaelyVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria; Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.
Heinz DrexelVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria; Private University of the Principality of Liechtenstein, Triesen, Liechtenstein; Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria; Drexel University College of Medicine, Philadelphia, PA, USA.
Axel MündleinVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.
Peter S BraundDepartment of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK; Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK; Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK; Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK.
Daniel KofinkDepartment of Cardiology, Heart and Lungs Division, UMC Utrecht, Utrecht, Netherlands.
Imo E HoeferLaboratory of Experimental Cardiology, UMC Utrecht, Utrecht, Netherlands.
Gerard PasterkampLaboratory of Experimental Cardiology, UMC Utrecht, Utrecht, Netherlands.
Arshed A QuyyumiEmory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA, USA.
Yi-An KoEmory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA, USA.
Jaana A HartialaUniversity of Southern California, Los Angeles, CA, USA.
Hooman AllayeeUniversity of Southern California, Los Angeles, CA, USA.
W H Wilson TangCleveland Clinic, Cleveland, OH, USA.
Stanley L HazenCleveland Clinic, Cleveland, OH, USA.
Niclas ErikssonUppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
Claes HeldUppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
Emil HagströmUppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
Lars WallentinUppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
Axel ÅkerblomUppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
Agneta SiegbahnUppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
Igor KarpUniversity of Montreal Hospital Research Centre (CRCHUM), University of Montreal, Montreal, QC, Canada; Department of Social and Preventive Medicine, University of Montreal, Montreal, QC, Canada; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Christopher LabosDepartment of Medicine, McGill University, Montreal, QC, Canada.
Louise PiloteDepartment of Medicine, McGill University, Montreal, QC, Canada; Division of General Internal Medicine, McGill University Health Centre, Montreal, QC, Canada; Division of Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada.
James C EngertDepartment of Medicine, McGill University, Montreal, QC, Canada.
James M BrophyDepartment of Medicine, McGill University, Montreal, QC, Canada.
George ThanassoulisDepartment of Medicine, McGill University, Montreal, QC, Canada.
Peter BogatyDepartment of Medicine, Université Laval, QC, Canada.
Wojciech SzczeklikJagielonian University Medical College, Kraków, Poland.
Marcin KaczorJagielonian University Medical College, Kraków, Poland.
Marek SanakJagielonian University Medical College, Kraków, Poland.
Salim S ViraniSection of Cardiology, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, USA.
Christie M BallantyneSection of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Vei-Vei LeeDepartment of Biostatistics 7, Epidemiology, Texas Heart Institute, Houston, TX, USA.
Eric BoerwinkleSchool of Public Health, University of Texas, Houston, TX, USA.
Michael V HolmesMedical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK.
Benjamin D HorneIntermountain Heart Institute, Intermountain Medical Center, University of Utah School of Medicine, Salt Lake City, UT, USA.
Aroon HingoraniInstitute of Cardiovascular Science Facultyof Population Health Science, University College London, London, UK.
Folkert W AsselbergsDepartment of Cardiology, Heart and Lungs Division, UMC Utrecht, Utrecht, Netherlands; Institute of Cardiovascular Science Facultyof Population Health Science, University College London, London, UK; Durrer Centre of Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, Netherlands.
Riyaz S PatelInstitute of Cardiovascular Science Facultyof Population Health Science, University College London, London, UK.
GENIUS-CHD consortium
Bernhard K KrämerFifth Department of Medicine, University Heidelberg, Mannheim, Germany.
Hubert ScharnaglClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria.
Danilo FliserDepartment of Internal Medicine IV, Saarland University Hospital, Homburg/Saar, Germany.
Winfried MärzFifth Department of Medicine, University Heidelberg, Mannheim, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria; Synlab Academy, Synlab Holding, Mannheim, Germany. Electronic address: winfried.maerz@medma.uni-heidelberg.de.
Thimoteus SpeerDepartment of Internal Medicine IV, Saarland University Hospital, Homburg/Saar, Germany.
Saarland University · DEUppsala University · SEHeidelberg University · DEMcGill University · CAUniversity College London · GBUniversity Medical Center Utrecht · NLJagiellonian University · PLMedical University of Graz · ATUniversity of Ottawa · CAUniversity of Verona · ITVorarlberg Institute for Vascular Investigation and Treatment · ATBaylor College of Medicine · USCleveland Clinic · USGlenfield Hospital · GBHaukeland University Hospital · NOHelsinki University Hospital · FILeiden University Medical Center · NLNew Zealand Brain Research Institute · NZUniversität Hamburg · DEUniversity of Bergen · NO

Funding

Structural Determinants Of Ceruloplasmin Inflammatory ActivityP01HL076491 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, EDWARD FRANKLIN · 2004 to 2019
$27.3M
Pharmacogenomic Evaluation of Antihypertensive ResponsesU01GM074492 · NIGMS · UNIVERSITY OF FLORIDA · PI COOPER-DEHOFF, RHONDA M, JOHNSON, JULIE A. · 2005 to 2014
$20.7M
SCCOR in Cardiac Dysfunction and DiseaseP50HL077113 · NHLBI · WASHINGTON UNIVERSITY · PI KELLY, DANIEL PATRICK · 2005 to 2009
$13.4M
Regression of Atherosclerosis CoreP01HL098055 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI DIDONATO, JOSEPH · 2010 to 2014
$12.1M
Genomic variants associated with angina and health status outcome after MIR01NR013396 · NINR · WASHINGTON UNIVERSITY · PI CRESCI, SHARON · 2011 to 2019
$4.5M
Nitrative stress in heart failureR01HL103931 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI TANG, WAI HONG WILSON · 2010 to 2014
$3.8M
Hypertension PharmacogeneticsR01HL074730 · NHLBI · UNIVERSITY OF FLORIDA · PI JOHNSON, JULIE A. · 2003 to 2006
$3.4M
Role of Glycine Metabolism in Cardiovascular DiseaseR01HL133169 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALLAYEE, HOOMAN · 2017 to 2020
$3.3M
British Heart Foundation FS/14/76/30933NHLBI NIH HHS P01 HL076491NHLBI NIH HHS P01 HL098055NHLBI NIH HHS P50 HL077113NHLBI NIH HHS R01 HL074730NHLBI NIH HHS R01 HL103931NHLBI NIH HHS R01 HL133169NIGMS NIH HHS U01 GM074492NINR NIH HHS R01 NR013396
6 · The paper itself

Abstract

backgroundLipoprotein(a) concentrations in plasma are associated with cardiovascular risk in the general population. Whether lipoprotein(a) concentrations or LPA genetic variants predict long-term mortality in patients with established coronary heart disease remains less clear.

methodsWe obtained data from 3313 patients with established coronary heart disease in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. We tested associations of tertiles of lipoprotein(a) concentration in plasma and two LPA single-nucleotide polymorphisms ([SNPs] rs10455872 and rs3798220) with all-cause mortality and cardiovascular mortality by Cox regression analysis and with severity of disease by generalised linear modelling, with and without adjustment for age, sex, diabetes diagnosis, systolic blood pressure, BMI, smoking status, estimated glomerular filtration rate, LDL-cholesterol concentration, and use of lipid-lowering therapy. Results for plasma lipoprotein(a) concentrations were validated in five independent studies involving 10 195 patients with established coronary heart disease. Results for genetic associations were replicated through large-scale collaborative analysis in the GENIUS-CHD consortium, comprising 106 353 patients with established coronary heart disease and 19 332 deaths in 22 studies or cohorts.

findingsThe median follow-up was 9·9 years. Increased severity of coronary heart disease was associated with lipoprotein(a) concentrations in plasma in the highest tertile (adjusted hazard radio [HR] 1·44, 95% CI 1·14-1·83) and the presence of either LPA SNP (1·88, 1·40-2·53). No associations were found in LURIC with all-cause mortality (highest tertile of lipoprotein(a) concentration in plasma 0·95, 0·81-1·11 and either LPA SNP 1·10, 0·92-1·31) or cardiovascular mortality (0·99, 0·81-1·2 and 1·13, 0·90-1·40, respectively) or in the validation studies.

interpretationIn patients with prevalent coronary heart disease, lipoprotein(a) concentrations and genetic variants showed no associations with mortality. We conclude that these variables are not useful risk factors to measure to predict progression to death after coronary heart disease is established.

fundingSeventh Framework Programme for Research and Technical Development (AtheroRemo and RiskyCAD), INTERREG IV Oberrhein Programme, Deutsche Nierenstiftung, Else-Kroener Fresenius Foundation, Deutsche Stiftung für Herzforschung, Deutsche Forschungsgemeinschaft, Saarland University, German Federal Ministry of Education and Research, Willy Robert Pitzer Foundation, and Waldburg-Zeil Clinics Isny.

Indexed as

Genetic Association StudiesPolymorphism, Single NucleotideBiomarkersCohort StudiesCoronary DiseaseEuropeFemaleHumansLipoprotein(a)MaleMiddle AgedPrognosisRisk FactorsSurvival RateBiomarkersLipoprotein(a)

Identifiers

PMID28566218
PMCPMC5651679
OpenAlexW2618542302

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.