ArticleJournal of affective disorders2017
Severity of anxiety- but not depression- is associated with oxidative stress in Major Depressive Disorder.
Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Oxidative Stress and Neuroimaging Alterations in Major Depressive Disorder: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Association between oxidative balance score and psychological disorders in adults.Scientific reports · 2026Article
- Systems Pharmacology and Multi-Omics Reveal Synergistic Antidepressant Mechanisms of Radix Bupleurum-Radix Paeoniae Alba via Oxidative Stress, Neuroimmune Balance, and Circadian Rhythm.Neuropsychiatric disease and treatment · 2026Article
- Oxidative stress and cognitive function in Chinese patients with major depressive disorder: the mediating role of depression severity.BMC psychiatry · 2025Article
- Exosomes from high-altitude cerebral edema patients induce cognitive dysfunction by altering oxidative stress responses in mice.Translational psychiatry · 2025Article
- Music therapy as a preventive intervention for postpartum depression: modulation of synaptic plasticity, oxidative stress, and inflammation in a mouse model.Translational psychiatry · 2025Article
- Macaiba palm pulp (Acrocomia intumescens Drude) improves memory and induces anxiolytic-like behavior in dyslipidemic rats.Metabolic brain disease · 2024Article
- Oxidative Stress is a New Avenue for Treatment of Neuropsychiatric Disorders: Hype of Hope?Current molecular medicine · 2024Review
- Digital Challenges: Investigating Computer Vision Syndrome in Thai Esports Through a Case-Control Approach.Clinical optometry · 2024Article
- Article
- Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression.Scientific reports · 2023Article
- Prevalence and characteristics of anxiety in patients with unconfirmed pulmonary nodules.The clinical respiratory journal · 2023Article
- Prognostic Factors Associated With Sleep Duration: Serum Pro-Oxidant/Antioxidant Balance and Superoxide Dismutase 1 as Oxidative Stress Markers and Anxiety/Depression.International journal of public health · 2023Article
- Metabolic syndrome, adiposity, diet, and emotional eating are associated with oxidative stress in adolescents.Frontiers in nutrition · 2023Article
- Time of exposure to social defeat stress during childhood and adolescence and redox dysregulation on long-lasting behavioral changes, a translational study.Translational psychiatry · 2022Article
- The Relationship between FAntioxidants (Basel, Switzerland) · 2022Article
- Antioxidant Biomolecules and Their Potential for the Treatment of Difficult-to-Treat Depression and Conventional Treatment-Resistant Depression.Antioxidants (Basel, Switzerland) · 2022Review
- Renin-angiotensin system: The underlying mechanisms and promising therapeutical target for depression and anxiety.Frontiers in immunology · 2022Review
- The critical issue linking lipids and inflammation: Clinical utility of stopping oxidative stress.Frontiers in cardiovascular medicine · 2022Review
- A cross-sectional study on the association of serum uric acid levels with depressive and anxiety symptoms in people with epilepsy.BMC psychiatry · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundOxidative stress is implicated in both depression and anxiety, but it is currently unclear whether this relates to syndromal diagnoses or trans-diagnostic dimensional symptoms. We examined the relationship between oxidative stress and severity of depression and anxiety symptoms in individuals with Major Depressive Disorder (MDD).
methodsPlasma oxidative stress markers F2-isoprostanes and oxidized glutathione (GSSG), and the antioxidant reduced glutathione (GSH), were assessed in 69 physically healthy, medication-free MDD subjects. Symptoms of anxiety and depression were assessed using the Hamilton Anxiety (HAM-A) and Hamilton Depression (HAM-D) Rating Scales. Total HAM-A and HAM-D scores, along with "core" anxiety and depression subscales, and individual HAM-D items "psychic anxiety" and "depressed mood," were related to oxidative stress markers. Analyses controlled for age, sex, BMI, and smoking.
resultsTotal HAM-A ratings were positively associated with F2-isoprostanes (β=.26, p=.042) and GSSG (β=.25, p=.049), but not GSH (β=.05, p=.711). Core anxiety severity was positively associated with F2-isoprostanes (β=.34, p=.012) and GSSG, although this did not reach significance (β=.24, p=.074). None of the biological markers were significantly associated with total HAM-D or core depression ratings (all p>.13). Subjects scoring high on "psychic anxiety" had elevated F2-isoprostanes (p=.030) and GSSG (p=.020). This was not seen with "depressed mood" scores (all p>.12). LIMITATIONS: We assessed peripheral oxidative markers, but their relationship to the brain is unclear.
conclusionsOxidative stress is more closely related to anxiety than depression symptoms in MDD. This highlights the importance of relating oxidative stress to specific symptoms and could provide new insights into the biological correlates of affective disorders.
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