Evidence map›Paper›PMID 28564607›Full record

ArticleCell reports2017

Specification and Diversification of Pericytes and Smooth Muscle Cells from Mesenchymoangioblasts.

Akhilesh Kumar, Saritha Sandra D'Souza, Oleg V Moskvin, Huishi Toh, Bowen Wang, Jue Zhang, Scott Swanson, Lian-Wang Guo, James A Thomson, Igor I Slukvin

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 231 citations in OpenAlex.

  1. Article
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  8. The fibroinflammatory response in cancer.Nature reviews. Cancer · 2025
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80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Akhilesh KumarWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Saritha Sandra D'SouzaWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Oleg V MoskvinWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA; Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI 53703, USA.
Huishi TohNeuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Bowen WangDepartment of Surgery, University of Wisconsin-Madison, Madison, WI 53792, USA.
Jue ZhangMorgridge Institute for Research, Madison, WI 53707, USA.
Scott SwansonMorgridge Institute for Research, Madison, WI 53707, USA.
Lian-Wang GuoDepartment of Surgery, University of Wisconsin-Madison, Madison, WI 53792, USA.
James A ThomsonMorgridge Institute for Research, Madison, WI 53707, USA; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53707, USA; Department of Molecular, Cellular & Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Igor I SlukvinWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53707, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53792, USA. Electronic address: islukvin@wisc.edu.
University of Wisconsin–Madison · USMorgridge Institute for Research · USUniversity of California, Santa Barbara · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
The Epigenotype of Human ES CellsP01GM081629 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI THOMSON, JAMES ALEXANDER · 2008 to 2012
$8.9M
Midwest Progenitor Cell ConsortiumU01HL099773 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI THOMSON, JAMES ALEXANDER · 2009 to 2015
$7.8M
BET Bromodomain proteins as Novel Epigenetic Targets for prevention of Intimal Hyperplasia after Vascular SurgeryR01HL133665 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GUO, LIANWANG · 2016 to 2019
$1.6M
NHLBI NIH HHS R01 HL133665NHLBI NIH HHS U01 HL099773NIGMS NIH HHS P01 GM081629NIH HHS P51 OD011106
6 · The paper itself

Abstract

Elucidating the pathways that lead to vasculogenic cells, and being able to identify their progenitors and lineage-restricted cells, is critical to the establishment of human pluripotent stem cell (hPSC) models for vascular diseases and development of vascular therapies. Here, we find that mesoderm-derived pericytes (PCs) and smooth muscle cells (SMCs) originate from a clonal mesenchymal progenitor mesenchymoangioblast (MB). In clonogenic cultures, MBs differentiate into primitive PDGFRβ

Indexed as

Cell DifferentiationBlood VesselsCollagenDrug CombinationsGene Expression ProfilingHumansLamininMesenchymal Stem CellsMesodermModels, BiologicalMuscle ContractionMyocytes, Smooth MuscleNeovascularization, PhysiologicPericytesProteoglycansCollagenDrug CombinationsLamininmatrigelProteoglycansdevelopmentmesenchymoangioblastpericytespluripotent stem cellssmooth muscles

Identifiers

PMID28564607
PMCPMC6428685
OpenAlexW2617216694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.