ArticleNature2017
Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles.
Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
79 citing papers in PubMed, 115 citations in OpenAlex.
- Oxytocin increases eye-gaze towards novel social and non-social stimuli.Social neuroscience · 2019Trial
- Hypothalamic-amygdala gating of caregiving-like prosocial behavior in mice.The Journal of clinical investigation · 2026Article
- Loss of oxytocin receptor function disrupts neural signatures of pair bonding and fidelity in the nucleus accumbens.Nature communications · 2026Article
- Love, death, and oxytocin: In memory of Larry Young.Progress in neurobiology · 2026Article
- Adult-to-infant unidirectional neural coupling mediates selective social learning in infants from the United Kingdom and Singapore.Nature communications · 2026Article
- Repeated Stress Escalates Aggression and Activity in Fronto-Limbic Regions in Cntnap2Genes, brain, and behavior · 2026Article
- Accumbal calcium-permeable AMPA receptors orchestrate neuronal ensembles underlying social attachment.Nature communications · 2026Article
- Backtracking α-synuclein pathology: social deficits precede motor symptoms in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Natural variation in the oxytocin receptor gene predicts social observation in female prairie voles.bioRxiv : the preprint server for biology · 2025Article
- Interaction Between Oxytocin and Dopamine Signaling: Focus on the Striatum.International journal of molecular sciences · 2025Review
- How dopamine guides our social world.Pharmacological reviews · 2025Review
- Experience-dependent maternal defense behavior mediated by profrontal cortical projections to the medial preoptic area in mice.Nature communications · 2025Article
- Optogenetic Mapping of Rhythmic Phase-Dependent Excitability in the Mouse Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural connectivity of oxytocin receptor-expressing neurons in the nucleus accumbens and their role in social attachment.Hormones and behavior · 2025Article
- Vocal recognition of partners by female prairie voles.iScience · 2025Article
- Information sharing within a social network is key to behavioral flexibility-Lessons from mice tested under seminaturalistic conditions.Science advances · 2025Article
- Article
- Sex differences in neural representations of social and nonsocial reward in the medial prefrontal cortex.Nature communications · 2024Article
- Vocal recognition of partners by female prairie voles.bioRxiv : the preprint server for biology · 2024Article
- Cell- and Pathway-Specific Disruptions in the Accumbens of Fragile X Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Adult pair bonding involves dramatic changes in the perception and valuation of another individual. One key change is that partners come to reliably activate the brain's reward system, although the precise neural mechanisms by which partners become rewarding during sociosexual interactions leading to a bond remain unclear. Here we show, using a prairie vole (Microtus ochrogaster) model of social bonding, how a functional circuit from the medial prefrontal cortex to nucleus accumbens is dynamically modulated to enhance females' affiliative behaviour towards a partner. Individual variation in the strength of this functional connectivity, particularly after the first mating encounter, predicts how quickly animals begin affiliative huddling with their partner. Rhythmically activating this circuit in a social context without mating biases later preference towards a partner, indicating that this circuit's activity is not just correlated with how quickly animals become affiliative but causally accelerates it. These results provide the first dynamic view of corticostriatal activity during bond formation, revealing how social interactions can recruit brain reward systems to drive changes in affiliative behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.