Evidence map›Paper›PMID 28562327›Full record

ArticleAging2017

The protein kinase MBK-1 contributes to lifespan extension in

Hildegard I D Mack, Peichuan Zhang, Bryan R Fonslow, John R Yates

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Loss ofbioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Hildegard I D MackDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, 94158, USA.
Peichuan ZhangDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, 94158, USA.
Bryan R FonslowDepartment of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
John R YatesDepartment of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Scripps Research Institute · USEnzo Life Sciences (United States) · USUniversity of California, San Francisco · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Signals from the reproductive system that regulate aging in C. elegansR01AG032435 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, HAO · 2009 to 2018
$3.3M
NIA NIH HHS R01 AG032435NIH HHS P40 OD010440
6 · The paper itself

Abstract

In

Indexed as

LongevityMutationAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsForkhead Transcription FactorsGene Expression RegulationGenotypePhenotypePhosphorylationProtein Serine-Threonine KinasesProtein-Tyrosine KinasesReceptor, InsulinReceptors, NotchTime FactorsCaenorhabditis elegans Proteinsdaf-16 protein, C elegansDAF-2 protein, C elegansForkhead Transcription FactorsGlp-1 protein, C eleganshematopoietic progenitor kinase 1Protein Serine-Threonine KinasesProtein-Tyrosine KinasesReceptor, InsulinReceptors, NotchagingDYRK1FOXOphosphorylationsignaling

Identifiers

PMID28562327
PMCPMC5472741
OpenAlexW2619718804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.