Evidence map›Paper›PMID 28562206›Full record

ArticleCell cycle (Georgetown, Tex.)2017

Lipopolysaccharide induces the differentiation of hepatic progenitor cells into myofibroblasts via activation of the Hedgehog signaling pathway.

Xiao-Rong Pan, Ying-Ying Jing, Wen-Ting Liu, Zhi-Peng Han, Rong Li, Yang Yang, Jing-Ni Zhu, Xiao-Yong Li, Pei-Pei Li, Li-Xin Wei

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Resident CD24Acta biochimica et biophysica Sinica · 2025
    Article
  4. Article
  5. Novel Therapeutic Targets in Liver Fibrosis.Frontiers in molecular biosciences · 2021
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Xiao-Rong Pana Department of Tumor Immunology and Gene Therapy center , Shanghai Eastern Hepatobiliary Surgery Hospital , Shanghai , China.
Ying-Ying Jinga Department of Tumor Immunology and Gene Therapy center , Shanghai Eastern Hepatobiliary Surgery Hospital , Shanghai , China.
Wen-Ting Liua Department of Tumor Immunology and Gene Therapy center , Shanghai Eastern Hepatobiliary Surgery Hospital , Shanghai , China.
Zhi-Peng Hana Department of Tumor Immunology and Gene Therapy center , Shanghai Eastern Hepatobiliary Surgery Hospital , Shanghai , China.
Rong Lia Department of Tumor Immunology and Gene Therapy center , Shanghai Eastern Hepatobiliary Surgery Hospital , Shanghai , China.
Yang Yanga Department of Tumor Immunology and Gene Therapy center , Shanghai Eastern Hepatobiliary Surgery Hospital , Shanghai , China.
Jing-Ni Zhua Department of Tumor Immunology and Gene Therapy center , Shanghai Eastern Hepatobiliary Surgery Hospital , Shanghai , China.
Xiao-Yong Lia Department of Tumor Immunology and Gene Therapy center , Shanghai Eastern Hepatobiliary Surgery Hospital , Shanghai , China.
Pei-Pei Lia Department of Tumor Immunology and Gene Therapy center , Shanghai Eastern Hepatobiliary Surgery Hospital , Shanghai , China.
Li-Xin Weia Department of Tumor Immunology and Gene Therapy center , Shanghai Eastern Hepatobiliary Surgery Hospital , Shanghai , China.
Second Military Medical University · CNEastern Hepatobiliary Surgery Hospital · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Normally, hepatic progenitor cells (HPCs) are activated and differentiate into hepatocytes or bile ductular cells to repair liver damage during liver injury. However, it remains controversial whether the abnormal differentiation of HPCs occurs under abnormal conditions. Lipopolysaccharide (LPS), a component of the microenvironment, promotes liver fibrosis. In the present study, HPCs promoted liver fibrosis in rats following carbon tetrachloride (CCl

Indexed as

Stem Cell TransplantationActinsAnimalsCarbon TetrachlorideCell DifferentiationCell LineChemical and Drug Induced Liver InjuryConnective Tissue Growth FactorGene Expression RegulationHedgehog ProteinsHepatocytesLipopolysaccharidesLiverLiver CirrhosisMaleMyofibroblastsActa2 protein, ratActinsCarbon TetrachlorideCCN2 protein, ratConnective Tissue Growth FactorGli1 protein, ratGLI3 protein, ratHedgehog ProteinsLipopolysaccharidesShh protein, ratZinc Finger Protein GLI1Zinc Finger Protein Gli3differentiationhepatic progenitor cellslipopolysaccharideliver fibrosismyofibroblasts

Identifiers

PMID28562206
PMCPMC5539817
OpenAlexW2617350741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.