ArticleACS synthetic biology2017
Switching Protein Localization by Site-Directed RNA Editing under Control of Light.
Article in ACS synthetic biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Light-Controlled Assembly and Disassembly of Covalent RNA-Protein Conjugates to Control RNA Base Editing.Molecules (Basel, Switzerland) · 2026Article
- Beyond The Nucleus: Translating Engineered Protein Localization To Chromatin Modifying Enzymes.Current opinion in biomedical engineering · 2026Article
- An improved SNAP-ADAR tool enables efficient RNA base editing to interfere with post-translational protein modification.Nature communications · 2024Article
- Profiling the interactome of oligonucleotide drugs by proximity biotinylation.Nature chemical biology · 2024Article
- A chemical magnet: Approaches to guide precise protein localization.Bioorganic & medicinal chemistry · 2024Article
- Precision RNA base editing with engineered and endogenous effectors.Nature biotechnology · 2023Review
- Precise and efficient C-to-U RNA base editing with SNAP-CDAR-S.Nucleic acids research · 2023Article
- RNA Editing Therapeutics: Advances, Challenges and Perspectives on Combating Heart Disease.Cardiovascular drugs and therapy · 2023Review
- Synthetic peptides for the precise transportation of proteins of interests to selectable subcellular areas.Frontiers in bioengineering and biotechnology · 2023Article
- Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo.Nature biotechnology · 2022Article
- CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo.Nature biotechnology · 2022Article
- Harnessing self-labeling enzymes for selective and concurrent A-to-I and C-to-U RNA base editing.Nucleic acids research · 2021Article
- Controlling Site-Directed RNA Editing by Chemically Induced Dimerization.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Light-control of cap methylation and mRNA translationChemical science · 2021Article
- Base editing: advances and therapeutic opportunities.Nature reviews. Drug discovery · 2020Review
- RNA editing of BFP, a point mutant of GFP, using artificial APOBEC1 deaminase to restore the genetic code.Scientific reports · 2020Article
- Off-Target Editing by CRISPR-Guided DNA Base Editors.Biochemistry · 2019Review
- Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs.Nature biotechnology · 2019Article
- Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides.Nature biotechnology · 2019Article
- Base editing: precision chemistry on the genome and transcriptome of living cells.Nature reviews. Genetics · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Site directed RNA editing is an engineered tool for the posttranscriptional manipulation of RNA and proteins. Here, we demonstrate the inclusion of additional N- and C-terminal protein domains in an RNA editing-dependent manner to switch between protein isoforms in mammalian cell culture. By inclusion of localization signals, a switch of the subcellular protein localization was achieved. This included the shift from the cytoplasm to the outer-membrane, which typically is inaccessible at the protein-level. Furthermore, the strategy allows to implement photocaging to achieve spatiotemporal control of isoform switching. The strategy does not require substantial genetic engineering, and might well complement current optogenetic and optochemical approaches.
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Registered trials
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