ArticleDevelopmental psychobiology2017
Neonatal abstinence syndrome: Neurobehavior at 6 weeks of age in infants with or without pharmacological treatment for withdrawal.
Article in Developmental psychobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurodevelopmental outcomes of prenatal opioid exposure and neonatal opioid withdrawal syndrome: A systematic review from birth to early adulthood.Journal of perinatology : official journal of the California Perinatal Association · 2026Pooled it
- Neonatal Abstinence Syndrome Severity Index Predicts 18-Month Neurodevelopmental Outcome in Neonates Randomized to Morphine or Methadone.The Journal of pediatrics · 2020Trial
- Neonatal Neurobehavior Predicts Neonatal Opioid Withdrawal Syndrome Severity Prior to Treatment Interventions.The Journal of pediatrics · 2025Article
- Abnormal neurobehavior profiles observed in the newborn period following low-to-moderate prenatal alcohol exposure.Alcohol, clinical & experimental research · 2025Article
- The Combined Contributions of Newborn Stress and Parenting Stress on Toddler Language Development.The Journal of pediatrics · 2024Article
- Prenatal and perinatal factors associated with neonatal neurobehavioral profiles in the ECHO Program.Pediatric research · 2023Article
- Effect of Neonatal Abstinence Syndrome Treatment Status and Maternal Depressive Symptomatology on Maternal Reports of Infant Behaviors.Journal of pediatric psychology · 2023Article
- Opioid, methamphetamine, and polysubstance use: perinatal outcomes for the mother and infant.Frontiers in pediatrics · 2023Review
- Effects of Pharmacologic Treatment for Neonatal Abstinence Syndrome on DNA Methylation and Neurobehavior: A Prospective Cohort Study.The Journal of pediatrics · 2022Article
- Psychotropic drug abuse in pregnancy and its impact on child neurodevelopment: A review.World journal of clinical pediatrics · 2022Review
- Integrated Review of the Assessment of Newborns With Neonatal Abstinence Syndrome.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2021Review
- Association of prenatal opiate exposure with youth outcomes assessed from infancy through adolescence.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Maternal responsivity and oxytocin in opioid-dependent mothers.Developmental psychobiology · 2020Article
- Article
- Prenatal Exposures Are Associated With Worse Neurodevelopmental Outcomes in Infants With Neonatal Opioid Withdrawal Syndrome.Frontiers in pediatrics · 2020Article
- Prenatal Opioid Exposure: Neurodevelopmental Consequences and Future Research Priorities.Pediatrics · 2019Review
- Early life stress and environmental influences on the neurodevelopment of children with prenatal opioid exposure.Neurobiology of stress · 2018Review
- Prenatal exposure to maternal depression and anxiety on imprinted gene expression in placenta and infant neurodevelopment and growth.Pediatric research · 2018Article
- Prenatal Opioid Exposure and Intermittent Hypoxemia in Preterm Infants: A Retrospective Assessment.Frontiers in pediatrics · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Use and abuse of prescription opioids and concomitant increase in Neonatal Abstinence Syndrome (NAS), a condition that may lead to protracted pharmacological treatment in more than 60% of infants, has tripled since 2000. This study assessed neurobehavioral development using the NICU Network Neurobehavioral Scale in 6-week old infants with prenatal methadone exposure who did (NAS+; n = 23) or did not (NAS-; n = 16) require pharmacological treatment for NAS severity determined by Finnegan Scale. An unexposed, demographically similar group of infants matched for age served as comparison (COMP; n = 21). NAS+, but not NAS- group, had significantly lower scores on the regulation (p < .01) and quality of movement (p < .01) summary scales than the COMP group. The NAS+ and NAS- groups had higher scores on the stress-abstinence scale than the COMP group (p < .05). NAS diagnosis (NAS +) was associated with poorer regulation and quality of movement at 6 weeks of age compared to infants without prenatal methadone exposure from the same demographic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.