Evidence map›Paper›PMID 28561758›Full record

ArticleNutrients2017

Lactobacillus reuteri I5007 Modulates Intestinal Host Defense Peptide Expression in the Model of IPEC-J2 Cells and Neonatal Piglets.

Hongbin Liu, Chengli Hou, Gang Wang, Hongmin Jia, Haitao Yu, Xiangfang Zeng, Philip A Thacker, Guolong Zhang, Shiyan Qiao

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 93 citations in OpenAlex.

  1. Trial
  2. Virulence · 2026
    Article
  3. Review
  4. Article
  5. Early-life intervention withFrontiers in microbiology · 2026
    Article
  6. Gut microbes · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. DEFA5-producing CD4Frontiers in immunology · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Comparative Genomics ofMicroorganisms · 2024
    Article
  16. Article
  17. Review
  18. Review
  19. Frontiers in microbiology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Hongbin LiuState Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, 100193, China. binhongliu@126.com.
Chengli HouState Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, 100193, China. houchengli@163.com.
Gang WangState Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, 100193, China. crazygang@126.com.
Hongmin JiaState Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, 100193, China. jiahongmin@126.com.
Haitao YuState Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, 100193, China. 15600660793@163.com.
Xiangfang ZengState Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, 100193, China. ziyangzxf@163.com.
Philip A ThackerDepartment of Animal and Poultry Science, University of Saskatchewan, SK S7N 5C5, Canada. phil.thacker@usask.ca.
Guolong ZhangDepartment of Animal Science, Oklahoma State University, Stillwater, OK 74074, USA. glenn.zhang@okstate.edu.
Shiyan QiaoState Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, 100193, China. qiaoshy@mafic.ac.cn.
China Agricultural University · CNOklahoma State University · USUniversity of Saskatchewan · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modulation of the synthesis of endogenous host defense peptides (HDPs) by probiotics represents a novel antimicrobial approach for disease control and prevention, particularly against antibiotic-resistant infections in human and animals. However, the extent of HDP modulation by probiotics is species dependent and strain specific. In the present study, The porcine small intestinal epithelial cell line (IPEC-J2) cells and neonatal piglets were used as in-vitro and in-vivo models to test whether

Indexed as

Limosilactobacillus reuteriAnimalsAnimals, NewbornAntimicrobial Cationic Peptidesbeta-DefensinsButyratesCell LineDiarrheaDNA, BacterialEpithelial CellsFatty Acids, VolatileFecesGastrointestinal MicrobiomeGene Expression RegulationIntestinal MucosaIntestinesAntimicrobial Cationic Peptidesbeta-DefensinsButyratesDNA, BacterialFatty Acids, VolatilePPAR gammaprotegrin-1Receptors, G-Protein-Coupledgut microbiotahost defense peptideintestinal epithelial cellsLactobacillus reuterineonatal piglets

Identifiers

PMID28561758
PMCPMC5490538
OpenAlexW2617187322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.