Evidence map›Paper›PMID 28561738›Full record

ArticleeLife2017

Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca

Chiwei Xu, Junjie Luo, Li He, Craig Montell, Norbert Perrimon

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 96 citations in OpenAlex.

  1. Article
  2. The RyR-like-FKBP12-PKA Complex Regulates Intracellular CaInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Host-Microbe Interactions in Drosophila Cancer.Advances in experimental medicine and biology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Chiwei XuDepartment of Genetics, Harvard Medical School, Boston, United States.
Junjie LuoDepartment of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, United States.
Li HeDepartment of Genetics, Harvard Medical School, Boston, United States.
Craig MontellDepartment of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, United States.
Norbert PerrimonDepartment of Genetics, Harvard Medical School, Boston, United States.ORCID 0000-0001-7542-472X
Harvard University · USUniversity of California, Santa Barbara · USHoward Hughes Medical Institute · US

Funding

New collections of dsRNAs and overexpression miRNA constructs to supplement RNAiR01GM067761 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI PERRIMON, NORBERT · 2003 to 2019
$15.5M
TRP CHANNEL SIGNALING COMPLEX AND ITS ROLE IN VISIONR01EY010852 · NEI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MONTELL, CRAIG · 1995 to 2021
$7.9M
Molecular Genetics of Taste TransductionR01DC007864 · NIDCD · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI CRAIG MONTELL · 2006 to 2026
$7.5M
Howard Hughes Medical InstituteNEI NIH HHS R01 EY010852NIDCD NIH HHS R01 DC007864NIGMS NIH HHS R01 GM067761
6 · The paper itself

Abstract

Precise regulation of stem cell activity is crucial for tissue homeostasis and necessary to prevent overproliferation. In the

Indexed as

Cell ProliferationOxidative StressAnimalsDrosophilaDrosophila ProteinsGastrointestinal TractIon ChannelsRyanodine Receptor Calcium Release ChannelSignal TransductionStem CellsTRPA1 Cation ChannelDrosophila ProteinsIon ChannelsRyanodine Receptor Calcium Release ChannelTRPA1 Cation ChannelTrpA1 protein, Drosophilacalciumcation channelscell biologydevelopmental biologyD. melanogasterRas/MAPKredoxstem cellstem cellstissue homeostasis

Identifiers

PMID28561738
PMCPMC5451214
OpenAlexW2620154098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.