ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2018
Near infrared spectroscopy for measuring changes in bone hemoglobin content after exercise in individuals with spinal cord injury.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04083794 (Exploration of Blood Flow Regulation to Bone in Humans), which is not on this map. Cited by 14 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exploration of Blood Flow Regulation to Bone in Humans
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Convergent Sensing: Integrating Biometric and Environmental Monitoring in Next-Generation Wearables.Biosensors · 2026Review
- Insights From Bone and Muscle Oxygenation Toward a More Comprehensive Model of Tissue Healing.The Journal of surgical research · 2025Article
- Broadband time domain diffuse optical characterization of human cadaver bone from 500 to 1100 nm.Scientific reports · 2025Article
- The role of sympathetic control in bone vasculature: insights from spinal cord injury.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Evidence of myogenic vasoconstriction in human bone vasculature.Physiological reports · 2025Article
- Nitric oxide-mediated vasodilation in human bone.Microcirculation (New York, N.Y. : 1994) · 2024Article
- Evaluation of Tibial Hemodynamic Response to Glucose Tolerance Test in Young Healthy Males and Females.Nutrients · 2023Article
- Effects of Posture and Walking on Tibial Vascular Hemodynamics Before and After 14 Days of Head-Down Bed Rest.JBMR plus · 2023Article
- Measuring tibial hemodynamics and metabolism at rest and after exercise using near-infrared spectroscopy.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2021Article
- A computationally efficient Monte-Carlo model for biomedical Raman spectroscopy.Journal of biophotonics · 2021Article
- Mechanisms of bone blood flow regulation in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- The Case for Measuring Long Bone Hemodynamics With Near-Infrared Spectroscopy.Frontiers in physiology · 2020Review
- Assessment of acute bone loading in humans using [European journal of nuclear medicine and molecular imaging · 2019Article
- Monitoring spinal cord hemodynamics and tissue oxygenation: a review of the literature with special focus on the near-infrared spectroscopy technique.Spinal cord · 2019Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Bone blood perfusion has an essential role in maintaining a healthy bone. However, current methods for measuring bone blood perfusion are expensive and highly invasive. This study presents a custom built near-infrared spectroscopy (NIRS) instrument to measure changes in bone blood perfusion. We demonstrated the efficacy of this device by monitoring oxygenated and deoxygenated hemoglobin changes in the human tibia during and after exercise in able-bodied and in individuals with spinal cord injury (SCI), a population with known impaired peripheral blood perfusion. Nine able-bodied individuals and six volunteers with SCI performed a 10 min rowing exercise (functional electrical stimulation rowing for those with SCI). With exercise, during rowing, able-bodied showed an increase in deoxygenated hemoglobin in the tibia. Post rowing, able-bodied showed an increase in total blood content, characterized by an increase in total hemoglobin content due primarily to an increase in deoxygenated hemoglobin. During rowing and post-rowing, those with SCI showed no change in total blood content in the tibia. The current study demonstrates that NIRS can non-invasively detect changes in hemoglobin concentration in the tibia. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:183-191, 2018.
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Registered trials
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