Evidence map›Paper›PMID 28560818›Full record

ArticleHuman brain mapping2017

Emotion regulation deficits in regular marijuana users.

Kaeli Zimmermann, Christina Walz, Raissa T Derckx, Keith M Kendrick, Bernd Weber, Bruce Dore, Kevin N Ochsner, René Hurlemann, Benjamin Becker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  5. Dose-related reductions in prefrontal recruitment during cognitive reappraisal following oral delta-9-tetrahydrocannabinol in posttraumatic stress disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kaeli ZimmermannDepartment of Psychiatry and Division of Medical Psychology, University of Bonn, Bonn, 53105, Germany.
Christina WalzCenter for Economics and Neuroscience, Department of Epileptology, University of Bonn, Bonn, 53105, Germany.
Raissa T DerckxDepartment of Psychiatry and Division of Medical Psychology, University of Bonn, Bonn, 53105, Germany.
Keith M KendrickKey Laboratory for NeuroInformation, School of Life Science and Technology and Center for Information in Medicine, University of Electronic Science and Technology of China, 610054, People's Republic of China.ORCID 0000-0002-0371-5904
Bernd WeberCenter for Economics and Neuroscience, Department of Epileptology, University of Bonn, Bonn, 53105, Germany.ORCID 0000-0002-7811-9605
Bruce DoreAnnenberg School for Communication, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.
Kevin N OchsnerDepartment of Psychology, Columbia University, New York, New York, 10027.
René HurlemannDepartment of Psychiatry and Division of Medical Psychology, University of Bonn, Bonn, 53105, Germany.
Benjamin BeckerKey Laboratory for NeuroInformation, School of Life Science and Technology and Center for Information in Medicine, University of Electronic Science and Technology of China, 610054, People's Republic of China.ORCID 0000-0002-9014-9671

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective regulation of negative affective states has been associated with mental health. Impaired regulation of negative affect represents a risk factor for dysfunctional coping mechanisms such as drug use and thus could contribute to the initiation and development of problematic substance use. This study investigated behavioral and neural indices of emotion regulation in regular marijuana users (n = 23) and demographically matched nonusing controls (n = 20) by means of an fMRI cognitive emotion regulation (reappraisal) paradigm. Relative to nonusing controls, marijuana users demonstrated increased neural activity in a bilateral frontal network comprising precentral, middle cingulate, and supplementary motor regions during reappraisal of negative affect (P < 0.05, FWE) and impaired emotion regulation success on the behavioral level (P < 0.05). Amygdala-focused analyses further revealed impaired amygdala downregulation in the context of decreased amygdala-dorsolateral prefrontal cortex functional connectivity (P < 0.05, FWE) during reappraisal in marijuana users relative to controls. Together, the present findings could reflect an unsuccessful attempt of compensatory recruitment of additional neural resources in the context of disrupted amygdala-prefrontal interaction during volitional emotion regulation in marijuana users. As such, impaired volitional regulation of negative affect might represent a consequence of, or risk factor for, regular marijuana use. Hum Brain Mapp 38:4270-4279, 2017. © 2017 Wiley Periodicals, Inc.

Indexed as

BrainBrain MappingCannabisCognitionCravingEmotional IntelligenceEmotionsExecutive FunctionHumansMagnetic Resonance ImagingMaleMarijuana AbuseNeural PathwaysNeuropsychological TestsVolitionYoung Adultamygdalamarijuana usenegative affectprefrontal cortexreappraisal

Identifiers

PMID28560818
PMCPMC6866842

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.