Evidence map›Paper›PMID 28560737›Full record

ArticleEuropean journal of heart failure2017

Reduced regional cerebral blood flow in patients with heart failure.

Bhaswati Roy, Mary A Woo, Danny J J Wang, Gregg C Fonarow, Ronald M Harper, Rajesh Kumar

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06326996 (Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - A Randomized Clinical Trial.), which is not on this map. Cited by 81 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 3 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06326996 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - A Randomized Clinical Trial.

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2026Enrolled52ConditionsCoronary Heart Disease, Coronary Artery Bypass GraftingArmsThiamine, Placebo
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 3 syntheses or guidelines pooled it, 109 citations in OpenAlex.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Bhaswati RoySchool of Nursing, University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Mary A WooSchool of Nursing, University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Danny J J WangDepartments of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Gregg C FonarowDivision of Cardiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Ronald M HarperNeurobiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Rajesh KumarBrain Research Institute, UCLA, Los Angeles, CA, USA.
University of California, Los Angeles · USAllen Institute for Brain Science · USOlive View-UCLA Medical Center · US

Funding

Blood-Brain Barrier Dysfunction and Brain Injury in Heart FailureR01NR014669 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, WOO, MARY ANN · 2014 to 2017
$1.9M
Central Autonomic Nervous System Regulation in Heart FailureR01NR013625 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, WOO, MARY ANN · 2012 to 2015
$1.7M
NINR NIH HHS R01 NR013625NINR NIH HHS R01 NR014669
6 · The paper itself

Abstract

aimsHeart failure (HF) patients show significant lateralized neural injury, accompanied by autonomic, mood and cognitive deficits. Both gray and white matter damage occurs and probably develops from altered cerebral blood flow (CBF), a consequence of impaired cardiac output. However, the distribution of regional CBF changes in HF patients is unknown, but is an issue in determining mechanisms of neural injury. Our aim was to compare regional CBF changes in HF with CBF in control subjects using non-invasive pseudo-continuous arterial spin labelling (ASL) procedures. METHODS AND

resultsWe collected pseudo-continuous ASL data from 19 HF patients [mean age 55.5 ± 9.1 years; mean body mass index 27.7 ± 5.3 kg/m

conclusionsHeart failure patients showed lower, and largely lateralized, CBF in multiple autonomic, mood and cognitive regulatory sites. The reduced CBF is likely to contribute to the lateralized brain injury, leading to the autonomic and neuropsychological deficits found in the condition.

Indexed as

Cerebrovascular CirculationBrainCerebrovascular DisordersElectron Spin Resonance SpectroscopyHeart FailureHumansMagnetic Resonance ImagingMaleMiddle AgedSpin LabelsSpin LabelsArterial spin labellingBrain imagingCerebral blood flowCognitionMagnetic resonance imaging

Identifiers

PMID28560737
PMCPMC5633487
OpenAlexW2619569429

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.