Evidence map›Paper›PMID 28560717›Full record

ReviewEuropean journal of heart failure2017

Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).

Veli-Pekka Harjola, Wilfried Mullens, Marek Banaszewski, Johann Bauersachs, Hans-Peter Brunner-La Rocca, Ovidiu Chioncel, Sean P Collins, Wolfram Doehner, Gerasimos S Filippatos, Andreas J Flammer and 16 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 7 pooled it
21.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

207 citing papers in PubMed, 7 syntheses or guidelines pooled it, 392 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Highlights in heart failure.ESC heart failure · 2019
    Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Article
  16. An integrated overview of acute heart failure: a narrative review of pathophysiological mechanisms and contributing factors.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Review
  17. Article
  18. Review
  19. Review
  20. Review

147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 20 institutions in 20 countries.

Veli-Pekka HarjolaEmergency Medicine, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Wilfried MullensDepartment of Cardiology, Ziekenhuis Oost Limburg, Genk, Belgium.
Marek BanaszewskiIntensive Cardiac Therapy Clinic, Institute of Cardiology, Warsaw, Poland.
Johann BauersachsDepartment of Cardiology and Angiology, Medical School Hannover, Hannover, Germany.
Hans-Peter Brunner-La RoccaDepartment of Cardiology, Maastricht University Medical Centre, Maastricht, the Netherlands.
Ovidiu ChioncelInstitute of Emergency in Cardiovascular Disease, University of Medicine Carol Davila, Bucharest, Romania.
Sean P CollinsDepartment of Emergency Medicine, Vanderbilt University Medical Centre, Nashville, TN, USA.
Wolfram DoehnerCentre for Stroke Research, Berlin, Germany.
Gerasimos S FilippatosNational and Kapodistrian University of Athens, School of Medicine, Athens University Hospital Attikon, Athens, Greece.
Andreas J FlammerUniversity Heart Centre, University Hospital Zurich, Zurich, Switzerland.
Valentin FuhrmannDivision of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.
Mitja LainscakDepartment of Internal Medicine, General Hospital Murska Sobota, Murska Sobota, Slovenia.
Johan LassusCardiology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Matthieu LegrandU942 Inserm, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Josep MasipConsorci Sanitari Integral (Public Health Consortium), University of Barcelona, Barcelona, Spain.
Christian MuellerDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Zoltán PappDivision of Clinical Physiology, Department of Cardiology, Research Centre for Molecular Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
John ParissisNational and Kapodistrian University of Athens, School of Medicine, Athens University Hospital Attikon, Athens, Greece.
Elke PlatzDepartment of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Alain RudigerCardio-Surgical Intensive Care Unit, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Frank RuschitzkaUniversity Heart Centre, University Hospital Zurich, Zurich, Switzerland.
Andreas SchäferDepartment of Cardiology and Angiology, Medical School Hannover, Hannover, Germany.
Petar M SeferovicDepartment of Internal Medicine, Belgrade University School of Medicine, Belgrade, Serbia.
Hadi SkouriDivision of Cardiology, Department of Internal Medicine, American University of Beirut Medical Centre, Beirut, Lebanon.
Mehmet Birhan YilmazDepartment of Cardiology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
Alexandre MebazaaU942 Inserm, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Medizinische Hochschule Hannover · DENational and Kapodistrian University of Athens · GRUniversity Hospital of Zurich · CHAmerican University of Beirut Medical Center · LBCarol Davila University of Medicine and Pharmacy · ROCharité - Universitätsmedizin Berlin · DEHarvard University · USHelsinki University Hospital · FIInserm · FRInstitute of Cardiology · PLMaastricht University Medical Centre · NLSivas Cumhuriyet Üniversitesi · TRUniversitat de Barcelona · ESUniversité Paris Cité · FRUniversity Clinical Centre · PLUniversity Hospital of Basel · CHUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Debrecen · HUUniversity of Helsinki · FIUniversity of Ljubljana · SI

Funding

Utility of Lung Ultrasound in Assessing Pulmonary Congestion in Heart FailureK23HL123533 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PLATZ, ELKE · 2015 to 2019
$881k
NHLBI NIH HHS K23 HL123533
6 · The paper itself

Abstract

Organ injury and impairment are commonly observed in patients with acute heart failure (AHF), and congestion is an essential pathophysiological mechanism of impaired organ function. Congestion is the predominant clinical profile in most patients with AHF; a smaller proportion presents with peripheral hypoperfusion or cardiogenic shock. Hypoperfusion further deteriorates organ function. The injury and dysfunction of target organs (i.e. heart, lungs, kidneys, liver, intestine, brain) in the setting of AHF are associated with increased risk for mortality. Improvement in organ function after decongestive therapies has been associated with a lower risk for post-discharge mortality. Thus, the prevention and correction of organ dysfunction represent a therapeutic target of interest in AHF and should be evaluated in clinical trials. Treatment strategies that specifically prevent, reduce or reverse organ dysfunction remain to be identified and evaluated to determine if such interventions impact mortality, morbidity and patient-centred outcomes. This paper reflects current understanding among experts of the presentation and management of organ impairment in AHF and suggests priorities for future research to advance the field.

Indexed as

CardiologyDiagnostic ImagingDisease ManagementHeart FailureMultiple Organ FailureSocieties, MedicalAcute DiseaseEuropeHumansHeart failureMultiple organ failureVenous congestion

Identifiers

PMID28560717
PMCPMC5734941
OpenAlexW2620823929

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.