ArticlePharmaceutical research2017
A Biocompatible Synthetic Lung Fluid Based on Human Respiratory Tract Lining Fluid Composition.
Article in Pharmaceutical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 62 citations in OpenAlex.
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- Source terms for benchmarking models of SARS-CoV-2 transmission via aerosols and droplets.Royal Society open science · 2022Review
- Comparison of the survival of different isolates of SARS-CoV-2 in evaporating aerosols.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2022Article
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- Decontamination of SARS-CoV-2 contaminated N95 filtering facepiece respirators using artificial sun lamps.Journal of applied microbiology · 2021Article
- Decontamination of SARS-CoV-2 contaminated N95 filtering facepiece respirators (FFRs) with moist heat generated by a multicooker.Letters in applied microbiology · 2021Article
- A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration.Frontiers in bioengineering and biotechnology · 2021Review
- Human airway construct model is suitable for studying transcriptome changes associated with indoor air particulate matter toxicity.Indoor air · 2020Article
- Development of new in vitro models of lung protease activity for investigating stability of inhaled biological therapies and drug delivery systems.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2020Article
- Use of PBPK Modeling To Evaluate the Performance of Dissolv It, a Biorelevant Dissolution Assay for Orally Inhaled Drug Products.Molecular pharmaceutics · 2019Article
- Effective delivery of the anti-mycobacterial peptide NZX in mesoporous silica nanoparticles.PloS one · 2019Article
- Design and development of a biorelevant simulated human lung fluid.Journal of drug delivery science and technology · 2018Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 4 countries.
Funding
Abstract
purposeTo characterise a biorelevant simulated lung fluid (SLF) based on the composition of human respiratory tract lining fluid. SLF was compared to other media which have been utilized as lung fluid simulants in terms of fluid structure, biocompatibility and performance in inhalation biopharmaceutical assays.
methodsThe structure of SLF was investigated using cryo-transmission electron microscopy, photon correlation spectroscopy and Langmuir isotherms. Biocompatibility with A549 alveolar epithelial cells was determined by MTT assay, morphometric observations and transcriptomic analysis. Biopharmaceutical applicability was evaluated by measuring the solubility and dissolution of beclomethasone dipropionate (BDP) and fluticasone propionate (FP), in SLF.
resultsSLF exhibited a colloidal structure, possessing vesicles similar in nature to those found in lung fluid extracts. No adverse effect on A549 cells was apparent after exposure to the SLF for 24 h, although some metabolic changes were identified consistent with the change of culture medium to a more lung-like composition. The solubility and dissolution of BDP and FP in SLF were enhanced compared to Gamble's solution.
conclusionThe SLF reported herein constitutes a biorelevant synthetic simulant which is suitable to study biopharmaceutical properties of inhalation medicines such as those being proposed for an inhaled biopharmaceutics classification system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.