ArticleWorld journal of pediatrics : WJP2017
Group B Streptococcus causes severe sepsis in term neonates: 8 years experience of a major Chinese neonatal unit.
Article in World journal of pediatrics : WJP, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Global patterns of antibiotic resistance in group BFrontiers in microbiology · 2025Pooled it
- Early versus late parenteral nutrition for critically ill term and late preterm infants.The Cochrane database of systematic reviews · 2020Pooled it
- Clinical Characteristics and Antimicrobial Resistance ofInfection and drug resistance · 2026Article
- Antimicrobial susceptibility profiles of invasive bacterial infections among children from low- and middle-income countries in the Western Pacific Region (WPRO) - a systematic review and meta-analysis.The Lancet regional health. Western Pacific · 2024Article
- Early versus late parenteral nutrition in term and late preterm infants: study protocol for a randomised controlled trial.BMC pediatrics · 2022Article
- Etiology and clinical characteristics of neonatal sepsis in different medical setting models: A retrospective multi-center study.Frontiers in pediatrics · 2022Article
- Bacteriological Profile and Antibiotic Susceptibility Pattern of Neonatal Septicemia and Associated Factors of ICU Hospitalization Days.Infection and drug resistance · 2022Article
- Risk Factors and Clinical Characteristics of Neonatal Acute Respiratory Distress Syndrome Caused by Early Onset Sepsis.Frontiers in pediatrics · 2022Article
- Clinical Laboratory Features of Microbes That Cause Neonatal Sepsis: An 8-Year Retrospective Study.Infection and drug resistance · 2022Article
- Pathogens distribution and antimicrobial resistance in bloodstream infections in twenty-five neonatal intensive care units in China, 2017-2019.Antimicrobial resistance and infection control · 2021Article
- Prognostic value of amplitude-integrated EEG in neonates with high risk of neurological sequelae.Annals of clinical and translational neurology · 2020Article
- Case report: whole genome sequencing based investigation of maternal-neonatal listeriosis in Sichuan, China.BMC infectious diseases · 2019Article
- Suppression of pulmonary group B streptococcal proliferation and translocation by surfactants in ventilated near-term newborn rabbits.Pediatric research · 2019Article
- Incidence, Bacterial Profiles, And Antimicrobial Resistance Of Culture-Proven Neonatal Sepsis In South China.Infection and drug resistance · 2019Article
- Multi-Drug ResistantInfection and drug resistance · 2019Article
- Newborn colonization and antibiotic susceptibility patterns of Streptococcus agalactiae at the University of Gondar Referral Hospital, Northwest Ethiopia.BMC pediatrics · 2018Article
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4 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundIn contrast to industrialized countries, the clinical characteristics of neonatal sepsis caused by Group B Streptococcus (GBS) are largely unexplored in China.
methodsA retrospective case series study was performed at a high-capacity neonatal unit in Shanghai, China from January 2008 to December 2015. Clinical characteristics of neonates with culture-proven GBS sepsis and antibiotic susceptibility of isolated strains were analyzed.
resultsForty-three term neonates were included during the study period. The majority (74.4%) had early-onset sepsis with symptoms of respiratory distress. Meningitis was significantly more common in lateonset sepsis than in early-onset sepsis (81.5% vs. 18.8%, P<0.0001). Approximately one third of all patients (n=16) developed severe sepsis, defined as sepsis with organ dysfunctions, and respiratory dysfunction/failure was the most common (32.6%). The in-hospital mortality rate of GBS sepsis was 4.7%. Neonates who progressed to severe sepsis had significantly lower pH level at the onset of symptoms than those who did not (7.26±0.12 vs. 7.39±0.05, P=0.006). Treatment of severe GBS sepsis required lots of medical resources including extracorporeal membrane oxygenation. All tested GBS strains were susceptible to penicillin, but the rate of resistance to clindamycin (84.0%) and erythromycin (88.0%) was high.
conclusionsGBS as a pathogen for neonatal sepsis has been receiving little attention in China. Our data demonstrated that GBS sepsis was likely to be fulminant. Early recognition followed by antibiotics and adequate supportive therapies was critical for successful treatment. Chinese clinicians should be aware of GBS infection when treating neonatal sepsis, especially in the absence of universal maternal GBS screening.
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