Evidence map›Paper›PMID 28560631›Full record

ReviewJournal of neurovirology2017

Genetics of HIV-associated sensory neuropathy and related pain in Africans.

Huguette Gaelle Ngassa Mbenda, Antonia Wadley, Zane Lombard, Catherine Cherry, Patricia Price, Peter Kamerman

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neurovirology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Wnt/Molecular pain
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huguette Gaelle Ngassa MbendaSchool of Physiology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Rd, Parktown, Johannesburg, 2193, South Africa. ngassagaelle@yahoo.fr.
Antonia WadleySchool of Physiology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Rd, Parktown, Johannesburg, 2193, South Africa.
Zane LombardDivision of Human Genetics, Faculty of Health Sciences, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.
Catherine CherrySchool of Physiology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Rd, Parktown, Johannesburg, 2193, South Africa.
Patricia PriceSchool of Physiology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Rd, Parktown, Johannesburg, 2193, South Africa.
Peter KamermanSchool of Physiology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Rd, Parktown, Johannesburg, 2193, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the use of safer antiretroviral medications, the rate of HIV-associated sensory neuropathy (HIV-SN), the most common neurological complication of HIV, remains high. This condition is often painful and has a negative effect on quality of life. Up to 90% of those with HIV-SN experience pain for which there is no effective analgesic treatment. Genetic factors are implicated, but there is a lack of a comprehensive body of research for African populations. This knowledge gap is even more pertinent as Africans are most affected by HIV. However, recent studies performed in Southern African populations have identified genes displaying potential as genetic markers for HIV-SN and HIV-SN-associated pain in Africans. Here, we review the published studies to describe current knowledge of genetic risk factors for this disease in Africa.

Indexed as

Genetic Predisposition to DiseaseAdultAfricaBlack PeopleCalcium-Calmodulin-Dependent Protein Kinase KinaseDNA, MitochondrialFemaleGene ExpressionHIV InfectionsHumansInterleukin-12 Subunit p40Interleukin-4MalePainPeripheral Nervous System DiseasesQuality of LifeCalcium-Calmodulin-Dependent Protein Kinase KinaseCAMKK2 protein, humanDNA, MitochondrialIL12B protein, humanIL4 protein, humanInterleukin-12 Subunit p40Interleukin-4AfricaGeneticsHIV neuropathyPain

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.