Evidence map›Paper›PMID 28560610›Full record

ArticleJournal of assisted reproduction and genetics2017

Association between growth dynamics, morphological parameters, the chromosomal status of the blastocysts, and clinical outcomes in IVF PGS cycles with single embryo transfer.

Oleksii O Barash, Kristen A Ivani, Susan P Willman, Evan M Rosenbluth, Deborah S Wachs, Mary D Hinckley, Sara Pittenger Reid, Louis N Weckstein

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Preimplantation Genetic Testing for Aneuploidy inInternational journal of fertility & sterility · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Oleksii O BarashReproductive Science Center of the San Francisco Bay Area, 100 Park Place, Suite 200, San Ramon, CA, 94583, USA. oleksii.barash@gmail.com.
Kristen A IvaniReproductive Science Center of the San Francisco Bay Area, 100 Park Place, Suite 200, San Ramon, CA, 94583, USA.
Susan P WillmanReproductive Science Center of the San Francisco Bay Area, 100 Park Place, Suite 200, San Ramon, CA, 94583, USA.
Evan M RosenbluthReproductive Science Center of the San Francisco Bay Area, 100 Park Place, Suite 200, San Ramon, CA, 94583, USA.
Deborah S WachsReproductive Science Center of the San Francisco Bay Area, 100 Park Place, Suite 200, San Ramon, CA, 94583, USA.
Mary D HinckleyReproductive Science Center of the San Francisco Bay Area, 100 Park Place, Suite 200, San Ramon, CA, 94583, USA.
Sara Pittenger ReidReproductive Science Center of the San Francisco Bay Area, 100 Park Place, Suite 200, San Ramon, CA, 94583, USA.
Louis N WecksteinReproductive Science Center of the San Francisco Bay Area, 100 Park Place, Suite 200, San Ramon, CA, 94583, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of the present study is to examine interconnection between speed of embryo development, the genetic status of the blastocysts, and clinical outcomes in IVF preimplantation genetic screening (PGS) cycles with single embryo transfer (SET).

methodsThe retrospective comparative study has been performed between January 2013 and January 2016. Seven hundred thirty-seven cycles of IVF treatment with PGS, followed by 503 SETs, were included in the study. Normally fertilized oocytes were hatched on day 3, were cultured to the blastocyst stage, and were biopsied only when at least three to seven cells were herniating from zona pellucida on the morning of day 5 (≤118 h) or day 6 (≥139 h). A total of 3705 embryos were analyzed for euploidy rates and blastocyst morphology. All embryos were vitrified after the biopsy, and selected embryos were subsequently thawed for a hormone replacement frozen embryo transfer cycle.

resultsThe euploidy rate was significantly higher among embryos biopsied on day 5 versus day 6: 59.44 ± 4.1 and 48.19 ± 3.8, respectively, p < 0.05. The difference in euploidy rates between embryos biopsied on day 5 versus day 6 in matched age groups increased from 5.83 to 25.46% with advancing maternal age. Our data demonstrated no statistically significant difference in euploidy rates between good-quality embryos biopsied on day 5 in the group of patients <38 years old and embryos in PGS cycles using donor oocytes: 71.12% (336/472) and 75.68% (221/292), respectively, p = 0.174, χ

conclusionsGood- and fair-quality embryos available for biopsy on day 5 have higher euploidy rates and have a higher chance to result in an ongoing pregnancy. Euploidy rate has significant variations within the same age group depending on the morphology of the blastocysts.

Indexed as

AdultBiopsyBlastocystChromosomes, HumanEmbryo ImplantationEmbryonic DevelopmentEmbryo TransferFemaleFertilization in VitroHumansMaternal AgePregnancyPregnancy RatePreimplantation DiagnosisRetrospective StudiesSingle Embryo TransferBlastocyst biopsyBlastocyst morphologyCCSEmbryo developmentEuploidy ratesIVFPreimplantation genetic screening

Identifiers

PMID28560610
PMCPMC5533677

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.