Observational studyThe journal of headache and pain2017
Symptoms of central sensitization and comorbidity for juvenile fibromyalgia in childhood migraine: an observational study in a tertiary headache center.
Observational study in The journal of headache and pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Quality of life in children suffering from headaches: a systematic literature review.The journal of headache and pain · 2023Pooled it
- The efficacy and safety of calcitonin gene-related peptide monoclonal antibody for episodic migraine: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Pooled it
- Characterizing migraine burden and treatment response using nationwide smartphone app-based data in Korea.The journal of headache and pain · 2026Article
- Exploring Cognitive, Behavioral, and Psychological Dimensions in Persistent Idiopathic Facial Pain and Other Chronic Orofacial Pain Conditions.Brain and behavior · 2026Article
- Youth with high-frequency headaches due to migraine are more vulnerable to non-cephalic pain complaints.Headache · 2025Article
- The Photo- and Phonosensitivity Avoidance Behavior Scales: Evaluating Clinical Utility in Pediatric Primary Chronic Headache.Children (Basel, Switzerland) · 2024Article
- Effects of OnabotulinumtoxinA on Allodynia and Interictal Burden of Patients with Chronic Migraine.Toxins · 2024Article
- Clinical Correlates of Osmophobia in Primary Headaches: An Observational Study in Child Cohorts.Journal of clinical medicine · 2023Article
- Emotional arousal and valence in patients with fibromyalgia: a pilot study.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Pediatric Migraine: Diagnosis and Management.Journal of clinical medicine · 2022Article
- Article
- Phenotyping Chronic Musculoskeletal Pain in Male and Female Adolescents: Psychosocial Profiles, Somatosensory Profiles and Pain Modulatory Profiles.Journal of pain research · 2022Article
- Cultural Validation of the Chinese Central Sensitization Inventory in Patients with Chronic Pain and its Predictive Ability of Comorbid Central Sensitivity Syndromes.Journal of pain research · 2022Article
- Development and Feasibility of the Headache-Related Light and Sound Sensitivity Inventories in Youth.Children (Basel, Switzerland) · 2021Article
- Osmophobia in primary headache patients: associated symptoms and response to preventive treatments.The journal of headache and pain · 2021Observational
- Central sensitization in migraine is related to restless legs syndrome.Journal of neurology · 2021Article
- Pathophysiological Bases of Comorbidity in Migraine.Frontiers in human neuroscience · 2021Review
- Cutaneous Allodynia in Migraine: A Narrative Review.Frontiers in neurology · 2021Review
- Efficacy of Multi-Modal Migraine Prophylaxis Therapy on Hyperacusis Patients.The Annals of otology, rhinology, and laryngology · 2020Article
- OnabotulinumtoxinA Is an Effective Treatment for Chronic Migraine in Patients With Comorbid Fibromyalgia.Frontiers in neurology · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCentral sensitization is an important epiphenomenon of the adult migraine, clinically expressed by allodynia, pericranial tenderness and comorbidity for fibromyalgia in a relevant number of patients. This study aimed to evaluate the frequency and the clinical characteristics of allodynia, pericranial tenderness, and comorbidity for Juvenile Fibromialgia (JFM) in a cohort of migraine children selected in a tertiary headache center.
methodsThis was an observational cross-sectional study on 8-15 years old migraine patients. Allodynia was assessed by a questionnaire. Pericranial tenderness and comorbidity for JFM as well as their possible association with poor quality of life and migraine related disability, and with other clinical symptoms as anxiety, depression, sleep disorders and pain catastrophizing, were also evaluated.
resultsOne hundred and fifty one patients were selected, including chronic migraine (n°47), migraine without aura (n° 92) and migraine with aura (n° 12) sufferers. Allodynia was reported in the 96,6% and pericranial tenderness was observed in the 68.8% of patients. Pericranial tenderness was more severe in patients with more frequent migraine and shorter sleep duration. Allodynia seemed associated with anxiety, pain catastrophizing and high disability scores. Comorbidity for JFM was present in the 0.03% ofpatients. These children presented with a severe depression and a significant reduction of quality of life as compared to the other patients.
conclusionsThis study outlined a relevant presence of symptoms of central sensitization among children with migraine. Severe allodynia and comorbidity for JFM seemed to cause a general decline of quality of life, which would suggest the opportunity of a routine assessment of these clinical features.
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