ArticleMolecular medicine reports2017
The expression of DNA methyltransferases3A is specifically downregulated in chorionic villi of early embryo growth arrest cases.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Epigenetic mechanisms in maternal-fetal crosstalk: inter- and trans-generational inheritance.Epigenomics · 2025Review
- Analysis of prenatal medication use and placental epigenetic gestational age in extremely low gestational age newborns (ELGANs) highlight relationships to aspirin use during pregnancy.Clinical epigenetics · 2025Article
- The role of global DNA methylation in citrinin induced toxicity:Toxicology reports · 2025Article
- Increased levels of DNA methyltransferases in the placentas of women affected by Placenta Accreta Spectrum lead to aberrant DNA methylation patterns.Journal of molecular histology · 2024Article
- Exercise enhances placental labyrinth trophoblast development by activation of PGC-1α and FNDC5/irisin†.Biology of reproduction · 2024Article
- The role of chromatin-modifying enzymes and histone modifications in the modulation of p16 gene in fumonisin BMycotoxin research · 2023Article
- Prepubertal nutritional modulation in the bull and its impact on sperm DNA methylation.Cell and tissue research · 2022Article
- Dysregulation of Placental Functions and Immune Pathways in Complete Hydatidiform Moles.International journal of molecular sciences · 2019Article
- An epigenetic association of malformations, adverse reproductive outcomes, and fetal origins hypothesis related effects.Journal of assisted reproduction and genetics · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to investigate the expression pattern of four DNA methyltransferases (DNMT1, DNMT3A, DNMT3B and DNMT3L) in placenta chorionic villi of early embryo growth arrest patients. Chorionic villous specimens were obtained from 40 pregnant patients diagnosed with early embryo growth arrest and 40 healthy women who underwent selective pregnancy termination. Reverse transcription‑quantitative polymerase chain reaction, immunohistochemistry and western blot analysis were performed to characterize the mRNA and protein expression of DNMTs in chorionic villous cells. It was identified, among the four DNMTs, DNMT3B presented the highest level of protein expression in both patient groups. Although the mRNA expressions of the four DNMTs were comparable, the DNMT3A protein was specifically downregulated in patients with early embryo growth arrest. Therefore, the current study suggests that an abnormal decrease in DNMT3A protein levels may be involved in the pathogenesis of early embryo growth arrest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.