Evidence map›Paper›PMID 28560367›Full record

ArticleBiomaterials science2017

Antimicrobial nitric oxide releasing surfaces based on S-nitroso-N-acetylpenicillamine impregnated polymers combined with submicron-textured surface topography.

Yaqi Wo, Li-Chong Xu, Zi Li, Adam J Matzger, Mark E Meyerhoff, Christopher A Siedlecki

Abstract read
In one paragraph

Article in Biomaterials science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Wearable nitric oxide-releasing antibacterial insert for preventing device-associated infections.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Smartphone compatible nitric oxide releasing insert to prevent catheter-associated infections.Journal of controlled release : official journal of the Controlled Release Society · 2022
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Synthesis and Characterization of a FluorinatedJournal of materials chemistry. B · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yaqi WoDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Li-Chong Xu
Zi Li
Adam J Matzger
Mark E Meyerhoff
Christopher A Siedlecki

Funding

Bactericidal, Nonthrombogenic Intravascular CathetersR01HL128337 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARTLETT, ROBERT H., MEYERHOFF, MARK E · 2015 to 2018
$2.8M
Advanced Nitric Oxide Release Bactericidal Urinary CathetersR42DK100161 · NIDDK · BIOCREDE, INC. · PI CHEN, HAO, MEYERHOFF, MARK E · 2015 to 2016
$1.4M
Improving drug bioavailability through solid form discovery SUPPLEMENTR01GM106180 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MATZGER, ADAM JAY · 2013 to 2016
$1.2M
Advanced Nitric Oxide Release Bactericidal Urinary CathetersR41DK100161 · NIDDK · BIOCREDE, INC. · PI CHEN, HAO, MEYERHOFF, MARK E · 2013 to 2013
$149k
NHLBI NIH HHS R01 HL128337NIDDK NIH HHS R41 DK100161NIDDK NIH HHS R42 DK100161NIGMS NIH HHS R01 GM106180
6 · The paper itself

Abstract

A novel dual functioning antimicrobial CarboSil 20 80A polymer material that combines physical topographical surface modification and nitric oxide (NO) release is prepared and evaluated for its efficacy in reducing bacterial adhesion in vitro. The new biomaterial is created via a soft lithography two-stage replication process to induce submicron textures on its surface, followed by solvent impregnation with the NO donor, S-nitroso-N-acetylpenicillamine (SNAP), to obtain long-term (up to 38 d) NO release. The NO releasing textured polymer surface is evaluated against four bacteria commonly known to cause infections in hospital settings and the results demonstrate that the combined strategy enables a synergistic effect on reducing the bacterial adhesion of Staphylococcus epidermidis and Pseudomonas aeruginosa bacteria.

Indexed as

Anti-Bacterial AgentsBacteriaBacterial AdhesionNitric OxidePolymersS-Nitroso-N-AcetylpenicillamineSurface PropertiesWettabilityAnti-Bacterial AgentsNitric OxidePolymersS-Nitroso-N-Acetylpenicillamine

Identifiers

PMID28560367
PMCPMC6290899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.