ArticleScience advances2017
Photonic-plasmonic hybrid single-molecule nanosensor measures the effect of fluorescent labels on DNA-protein dynamics.
Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 77 citations in OpenAlex.
- Elevated plasma Tau-PT217 linked to decreased hippocampal functional connectivity in patients with knee osteoarthritis.Brain research · 2025Article
- Influence of point mutations on PR65 conformational adaptability: Insights from molecular simulations and nanoaperture optical tweezers.Science advances · 2024Article
- A deep learning method for empirical spectral prediction and inverse design of all-optical nonlinear plasmonic ring resonator switches.Scientific reports · 2024Article
- Energy landscape of conformational changes for a single unmodified protein.Npj biosensing · 2024Article
- Ultraviolet Resonant Nanogap Antennas with Rhodium Nanocube Dimers for Enhancing Protein Intrinsic Autofluorescence.ACS nano · 2023Article
- Sevoflurane anaesthesia induces cognitive impairment in young mice through sequential tau phosphorylation.British journal of anaesthesia · 2023Article
- Single-Molecule Optical Biosensing: Recent Advances and Future Challenges.ACS physical chemistry Au · 2023Review
- Nanogap enhancement of the refractometric sensitivity at quasi-bound states in the continuum in all-dielectric metasurfaces.Nanophotonics (Berlin, Germany) · 2023Article
- Unveiling atom-photon quasi-bound states in hybrid plasmonic-photonic cavity.Nanophotonics (Berlin, Germany) · 2022Article
- Single-molecule optofluidic microsensor with interface whispering gallery modes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Atomistic Simulations of Functionalized Nano-Materials for Biosensors Applications.International journal of molecular sciences · 2022Review
- Testosterone attenuates sevoflurane-induced tau phosphorylation and cognitive impairment in neonatal male mice.British journal of anaesthesia · 2021Article
- Infrared Polaritonic Biosensors Based on Two-Dimensional Materials.Molecules (Basel, Switzerland) · 2021Review
- Microfluidics-Based Plasmonic Biosensing System Based on Patterned Plasmonic Nanostructure Arrays.Micromachines · 2021Review
- The anesthetic sevoflurane induces tau trafficking from neurons to microglia.Communications biology · 2021Article
- Review of biosensing with whispering-gallery mode lasers.Light, science & applications · 2021Review
- Selectively enhanced Raman/fluorescence spectra in photonic-plasmonic hybrid structures.Nanoscale advances · 2020Article
- Critical Review: digital resolution biomolecular sensing for diagnostics and life science research.Lab on a chip · 2020Review
- Photonic Crystal Nanobeam Cavities for Nanoscale Optical Sensing: A Review.Micromachines · 2020Review
- Towards biological applications of nanophotonic tweezers.Current opinion in chemical biology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current methods to study molecular interactions require labeling the subject molecules with fluorescent reporters. However, the effect of the fluorescent reporters on molecular dynamics has not been quantified because of a lack of alternative methods. We develop a hybrid photonic-plasmonic antenna-in-a-nanocavity single-molecule biosensor to study DNA-protein dynamics without using fluorescent labels. Our results indicate that the fluorescein and fluorescent protein labels decrease the interaction between a single DNA and a protein due to weakened electrostatic interaction. Although the study is performed on the DNA-XPA system, the conclusion has a general implication that the traditional fluorescent labeling methods might be misestimating the molecular interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.