Evidence map›Paper›PMID 28560324›Full record

ArticleScience advances2017

CRISPR/Cas9 gene drives in genetically variable and nonrandomly mating wild populations.

Douglas W Drury, Amy L Dapper, Dylan J Siniard, Gabriel E Zentner, Michael J Wade

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 125 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Biology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Parental-effect gene-drive elements under partial selfing, or why dobioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Gene drives gaining speed.Nature reviews. Genetics · 2022
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Douglas W DruryDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Amy L DapperDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0001-8580-6676
Dylan J SiniardDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Gabriel E ZentnerDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0002-0801-7646
Michael J WadeDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Indiana University Bloomington · US

Funding

The effect of coinheritance on host-symbiont coevolutionR01GM084238 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI WADE, MICHAEL J · 2008 to 2015
$1.6M
NIGMS NIH HHS R01 GM084238
6 · The paper itself

Abstract

Synthetic gene drives based on CRISPR/Cas9 have the potential to control, alter, or suppress populations of crop pests and disease vectors, but it is unclear how they will function in wild populations. Using genetic data from four populations of the flour beetle

Indexed as

CRISPR-Cas SystemsGenetic VariationModels, GeneticAnimalsReproductionTriboliumCRISPR/Cas9gene drivegenetic variationimmune to driveinbreedingnonrandom matingpopulation engineeringPopulation Geneticspopulation suppressionselfish gene

Identifiers

PMID28560324
PMCPMC5438214
OpenAlexW2949834184

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.