ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2017
Resting-state network dysfunction in Alzheimer's disease: A systematic review and meta-analysis.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 257 papers, 5 of them syntheses that pooled it.
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Who cites it
257 citing papers in PubMed, 5 syntheses or guidelines pooled it, 442 citations in OpenAlex.
- Tracking electrophysiological signatures of Alzheimer's disease: a systematic review of multimodal studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Systematic Review of Different Neuroimaging Correlates in Mild Cognitive Impairment and Alzheimer's Disease.Clinical neuroradiology · 2021Pooled it
- Diagnostic power of resting-state fMRI for detection of network connectivity in Alzheimer's disease and mild cognitive impairment: A systematic review.Human brain mapping · 2021Pooled it
- Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature.BMC medicine · 2021Pooled it
- Brain Functional and Structural Changes in Alzheimer's Disease With Sleep Disorders: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- From convergence insufficiency to functional reorganization: A longitudinal randomized controlled trial of treatment-induced connectivity plasticity.CNS neuroscience & therapeutics · 2024Trial
- Positive affect disrupts neurodegeneration effects on cognitive training plasticity in older adults.Social cognitive and affective neuroscience · 2024Trial
- Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients: Results of feasibility and pilot studies.PloS one · 2022Trial
- Network-level functional connectivity is associated with longitudinal tau accumulation and amyloid-dependent cognitive decline in preclinical Alzheimer's disease.Research square · 2026Article
- Autism and Neurodegeneration: Distinct Disorders or a Shared Biological Continuum?Brain sciences · 2026Review
- Large-Scale Neural Recording Technologies for Investigating Circuit Dysfunction and Functional Biomarker Discovery in Animal Models of Alzheimer's Disease.International journal of molecular sciences · 2026Review
- Normative brain-state trajectories reveal deviation from healthy aging in AD.bioRxiv : the preprint server for biology · 2026Article
- A local-to-distant shift in dynamic brain connectivity marks early Alzheimer's risk.GeroScience · 2026Article
- Centralized Review of Alzheimer's Disease and Related Dementias Biomedical Repositories and Computational Methods.Bioengineering (Basel, Switzerland) · 2026Review
- Resting-state functional connectivity and cognitive impairment after COVID-19 infection: Evidence from a large-scale fMRI study.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Iron accumulation in the substantia nigra is linked to functional network connectivity alterations in early-stage Parkinson's Disease: an exploratory study.NPJ Parkinson's disease · 2026Article
- Telecommunication-inspired network models of healthy and diseased brains.Scientific reports · 2026Article
- Elucidating the Neurobiological Underpinnings of Mild Behavioral Impairment in Tauopathies: Clinical and Molecular Insights.International journal of molecular sciences · 2026Review
- The electrophysiological basis of resting-state fMRI hyperconnectivity in early Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Causal relationships between alzheimer's disease genetics and brain connectivity alterations: a multi-modal mendelian randomization study with transcriptomic validation of 191 rs-fMRI and 635 DTI neuroimaging traits.Brain imaging and behavior · 2026Article
197 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe performed a systematic review and meta-analysis of the Alzheimer's disease (AD) literature to examine consistency of functional connectivity alterations in AD dementia and mild cognitive impairment, using resting-state functional magnetic resonance imaging.
methodsStudies were screened using a standardized procedure. Multiresolution statistics were performed to assess the spatial consistency of findings across studies.
resultsThirty-four studies were included (1363 participants, average 40 per study). Consistent alterations in connectivity were found in the default mode, salience, and limbic networks in patients with AD dementia, mild cognitive impairment, or in both groups. We also identified a strong tendency in the literature toward specific examination of the default mode network. DISCUSSION: Convergent evidence across the literature supports the use of resting-state connectivity as a biomarker of AD. The locations of consistent alterations suggest that highly connected hub regions in the brain might be an early target of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.