ArticleCanine genetics and epidemiology2017
Correlation of neuter status and expression of heritable disorders.
Article in Canine genetics and epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The association between gonadectomy and timing of gonadectomy, and the risk of canine cranial cruciate ligament disease: A systematic review and meta-analysis.Veterinary surgery : VS · 2025Pooled it
- Prevalence and potential risk factors associated with idiopathic epilepsy in Golden Retrievers.Journal of veterinary internal medicine · 2026Article
- Gonadectomy and Its Association with Orthopedic and Neoplastic Disorders: A Retrospective Study in Belgium-Part I (Bitches).Life (Basel, Switzerland) · 2026Article
- Cohort profile of the first 2,000 canine enrolees in the Mars Petcare Biobank: demographic, hematologic and serum biochemistry results from March 2022 to December 2024.BMC veterinary research · 2026Article
- Cumulative gonadal hormone exposure is nonlinearly associated with risk of canine cranial cruciate ligament disease: a generalised additive model analysis of 20,590 dogs (1988-2023).The Journal of small animal practice · 2026Article
- Casuistry of oncological diseases in dogs, focusing on bone tumors treated at the Veterinary Hospital of the University of the Republic, Uruguay (2018-2023).Brazilian journal of veterinary medicine · 2026Article
- Gastric Dilatation-Volvulus in Dogs: Analysis of 130 Cases in a Single Institution.Animals : an open access journal from MDPI · 2025Article
- The effect of neuter status on longevity in the Rottweiler dog.Scientific reports · 2023Article
- The effects of sex and neuter status on trauma survival in dogs: A Veterinary Committee on Trauma registry study.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2022Article
- Life tables of annual life expectancy and mortality for companion dogs in the United Kingdom.Scientific reports · 2022Article
- Cranial Cruciate Ligament Rupture in Dogs: Review on Biomechanics, Etiopathogenetic Factors and Rehabilitation.Veterinary sciences · 2021Review
- Prevalence of Reproductive Disorders including Mammary Tumors and Associated Mortality in Female Dogs.Veterinary sciences · 2021Article
- Unravelling the health status of brachycephalic dogs in the UK using multivariable analysis.Scientific reports · 2020Article
- Neutering is associated with developing hemangiosarcoma in dogs in the Veterinary Medical Database: An age and time-period matched case-control study (1964-2003).The Canadian veterinary journal = La revue veterinaire canadienne · 2020Article
- Desexing Dogs: A Review of the Current Literature.Animals : an open access journal from MDPI · 2019Review
- Demographic characteristics, site and phylogenetic distribution of dogs with appendicular osteosarcoma: 744 dogs (2000-2015).PloS one · 2019Article
- A Review of the Impact of Neuter Status on Expression of Inherited Conditions in Dogs.Frontiers in veterinary science · 2019Review
- Article
- Association of cancer-related mortality, age and gonadectomy in golden retriever dogs at a veterinary academic center (1989-2016).PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGonadectomy, or neutering, is a very common surgery for dogs having many positive effects on behavior, health, and longevity. There are also certain risks associated with neutering including the development of orthopedic conditions, cognitive decline, and a predisposition to some neoplasias. This study was designed specifically to identify if a correlation exists between neuter status and inherited conditions in a large aggregate cohort of dogs representing many different breeds.
resultsNeutered dogs were at less risk for early and congenital conditions (aortic stenosis, early onset cataracts, mitral valve disease, patent ductus arteriosus, portosystemic shunt, and ventricular septal defect) than intact dogs. Neutering was also associated with reduced risk of dilated cardiomyopathy and gastric dilatation volvulus in males. Neutering was significantly associated with an increased risk for males and females for cancers (hemangiosarcoma, hyperadrenocorticism, lymphoma, mast cell tumor, and osteosarcoma), ruptured anterior cruciate ligament and epilepsy. Intervertebral disk disease was associated with increased risk in females only. For elbow dysplasia, hip dysplasia, lens luxation, and patellar luxation neutering had no significant effect on the risk for those conditions. Neutering was associated with a reduced risk of vehicular injury, a condition chosen as a control.
conclusionsIn this retrospective study, several conditions showed an increased risk associated with neutering whereas other conditions were less likely to be expressed in neutered dogs. The complexity of the interactions between neutering and inherited conditions underscores the need for reflective consultation between the client and the clinician when considering neutering. The convenience and advantages of neutering dogs that will not be included in a breeding program must be weighed against possible risk associated with neutering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.