Evidence map›Paper›PMID 28559988›Full record

ArticleAmerican journal of translational research2017

MiR-31 is involved in the high glucose-suppressed osteogenic differentiation of human periodontal ligament stem cells by targeting Satb2.

Lei Zhen, Xuewei Jiang, Yan Chen, Desheng Fan

Abstract read
In one paragraph

Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Role of microRNA in Diabetic Osteoporosis.Molecular biotechnology · 2025
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  20. Role of microRNAs in Diabetes-Associated Periodontitis: A Scoping Review.Journal of International Society of Preventive & Community Dentistry
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lei ZhenDepartment of Periodontology, Shanghai Stomatological Hospital, Fudan UniversityShanghai 200001, China.
Xuewei JiangDepartment of Periodontology, Shanghai Stomatological Hospital, Fudan UniversityShanghai 200001, China.
Yan ChenDepartment of Periodontology, Shanghai Stomatological Hospital, Fudan UniversityShanghai 200001, China.
Desheng FanDepartment of Pathology, Shanghai Tongji Hospital, School of Medicine, Tongji UniversityShanghai 200065, China.
Shanghai Stomatological Hospital · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease that gives rise to impaired bone remodeling. Increasing evidences have shown that miRNAs are associated with osteogenic differentiation of stem cells. However, the underlying mechanism that links DM-induced HG conditions and impaired osteogenic differentiation capacity of periodontal ligament stem cells (PDLSCs) still remains unclear. In this study, we found that diabetic mice with increased miR-31 level in periodontal ligaments exhibited greater bone loss.

Indexed as

high glucoseMiR-31osteogenic differentiationperiodontal ligament stem cellsSatb2

Identifiers

PMID28559988
PMCPMC5446520
OpenAlexW3008365814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.