Evidence map›Paper›PMID 28559932›Full record

ArticleJournal of neurodevelopmental disorders2017

Exploring the heterogeneity of neural social indices for genetically distinct etiologies of autism.

Caitlin M Hudac, Holly A F Stessman, Trent D DesChamps, Anna Kresse, Susan Faja, Emily Neuhaus, Sara Jane Webb, Evan E Eichler, Raphael A Bernier

Open access · goldAbstract read
In one paragraph

Article in Journal of neurodevelopmental disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Neural Correlates for Anticipating and Observing Goal-Directed Actions in Autism.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. History of concussion impacts electrophysiological correlates of working memory.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2018
    Article
  15. Article
  16. Clinical phenotype of ASD-associatedMolecular autism · 2017
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Caitlin M HudacDepartment of Psychiatry and Behavioral Sciences, University of Washington, CHDD Box 357920, Seattle, WA 98195 USA.
Holly A F StessmanDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195 USA.
Trent D DesChampsDepartment of Psychiatry and Behavioral Sciences, University of Washington, CHDD Box 357920, Seattle, WA 98195 USA.
Anna KresseCenter for Child Health, Behavior, and Disabilities, Seattle Children's Research Institute, Seattle, WA 98145 USA.
Susan FajaBoston Children's Hospital and Division of Developmental Medicine, Harvard School of Medicine, Boston, MA 02215 USA.
Emily NeuhausCenter for Child Health, Behavior, and Disabilities, Seattle Children's Research Institute, Seattle, WA 98145 USA.
Sara Jane WebbDepartment of Psychiatry and Behavioral Sciences, University of Washington, CHDD Box 357920, Seattle, WA 98195 USA.
Evan E EichlerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195 USA.
Raphael A BernierDepartment of Psychiatry and Behavioral Sciences, University of Washington, CHDD Box 357920, Seattle, WA 98195 USA.
Seattle Children's Hospital · USUniversity of Washington · USBoston Children's Hospital · US

Funding

INTERDISCIPLINARY TRAINING IN GENOMIC SCIENCEST32HG000035 · NHGRI · UNIVERSITY OF WASHINGTON · PI Bruce Colston Trapnell · 1995 to 2026
$24.2M
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI DANIEL DOHERTY · 2020 to 2026
$9.9M
Sporadic Mutations and Autism Spectrum DisordersR01MH101221 · NIMH · UNIVERSITY OF WASHINGTON · PI EICHLER, EVAN · 2013 to 2025
$9.2M
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI DOHERTY, DANIEL · 2014 to 2019
$7.9M
Phenotypic Characterization of Gene Disrupting Mutations in ASDR01MH100047 · NIMH · UNIVERSITY OF WASHINGTON · PI BERNIER, RAPHAEL A · 2014 to 2018
$2.1M
NHGRI NIH HHS T32 HG000035NICHD NIH HHS P50 HD103524NICHD NIH HHS U54 HD083091NIMH NIH HHS R01 MH100047NIMH NIH HHS R01 MH101221
6 · The paper itself

Abstract

backgroundAutism spectrum disorder (ASD) is a genetically and phenotypically heterogeneous disorder. Promising initiatives utilizing interdisciplinary characterization of ASD suggest phenotypic subtypes related to specific likely gene-disrupting mutations (LGDMs). However, the role of functionally associated LGDMs in the neural social phenotype is unknown.

methodsIn this study of 26 children with ASD (

resultsDiagnostic comparisons were consistent with prior work suggesting aberrant mu attenuation in ASD within the upper mu band (10-12 Hz), but typical patterns within the lower mu band (8-10 Hz). Preliminary exploration indicated distinct social sensitization patterns (i.e., increasing mu attenuation for social motion) for children with an LGDM that is primarily expressed during embryonic development. In contrast, children with an LGDM primarily expressed post-embryonic development exhibited stable typical patterns of lower mu attenuation. Neural social indices were associated with social responsiveness, but not cognition.

conclusionsThese findings suggest unique neurophysiological profiles for certain genetic etiologies of ASD, further clarifying possible genetic functional subtypes of ASD and providing insight into mechanisms for targeted treatment approaches.

Indexed as

Autism spectrum disorders (ASD)Electroencephalography (EEG)Likely gene-disrupting mutationsMolecular subtypingMu rhythm attenuationSocial cognitionSocial perception

Identifiers

PMID28559932
PMCPMC5446693
OpenAlexW2620507546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.