ArticleFrontiers in human neuroscience2017
Aberrant Insula-Centered Functional Connectivity in Psychogenic Erectile Dysfunction Patients: A Resting-State fMRI Study.
Article in Frontiers in human neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 35 citations in OpenAlex.
- The role of anterior and posterior insula in male genital response and in visual attention: an exploratory multimodal fMRI study.Scientific reports · 2020Trial
- Penile sympathetic skin response in patients with non-organic erectile dysfunction: a Cross-Sectional Study.International journal of impotence research · 2026Article
- Erectile Dysfunction in Diabetes Mellitus: A Comprehensive Narrative Review of Pathophysiology, Genetic Association Studies and Therapeutic Approaches.Endocrinology, diabetes & metabolism · 2025Review
- Altered gray matter morphometry in psychogenic erectile dysfunction patients: A Surface-based morphometry study.Scientific reports · 2025Article
- Altered regional brain activity and functional connectivity in primary intravaginal anejaculation patients revealed by resting-state fMRI.Asian journal of andrology · 2024Article
- Electroacupuncture for psychogenic erectile dysfunction: A resting-state functional magnetic resonance imaging study exploring the alteration of fractional amplitude of low frequency fluctuation.Frontiers in human neuroscience · 2023Article
- Neurophysiology of male sexual arousal-Behavioral perspective.Frontiers in behavioral neuroscience · 2023Review
- Differences in structural connectivity between diabetic and psychological erectile dysfunction revealed by network-based statistic: A diffusion tensor imaging study.Frontiers in endocrinology · 2022Article
- Convergent and Divergent Structural Connectivity of Brain White Matter Network Between Patients With Erectile Dysfunction and Premature Ejaculation: A Graph Theory Analysis Study.Frontiers in neurology · 2022Article
- Altered Regional Homogeneity in Patients With Diabetic Erectile Dysfunction: A Resting-State fMRI Study.Frontiers in endocrinology · 2022Article
- Potential biomarkers for distinguishing primary from acquired premature ejaculation: A diffusion tensor imaging based network study.Frontiers in neuroscience · 2022Article
- Heart Rate Variability and Erectile Function in Younger Men: A Pilot Study.Applied psychophysiology and biofeedback · 2021Article
- Associations Between Altered Cerebral Activity Patterns and Psychosocial Disorders in Patients With Psychogenic Erectile Dysfunction: A Mediation Analysis of fMRI.Frontiers in psychiatry · 2020Article
- Effects of Chaihu-Shugan-San capsule for psychogenic erectile dysfunction: Study protocol of a randomized placebo-controlled trial.Medicine · 2019Article
- Neuroimaging biomarkers of psychogenic erectile dysfunction: protocol for a systematic review.BMJ open · 2019Article
- Brain Imaging of Human Sexual Response: Recent Developments and Future Directions.Current sexual health reports · 2017Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most previous studies exploring the neural mechanism of psychogenic erectile dysfunction (pED) focused on brain activity under tasks. We suggest that the resting brain activity is equally important in pED studies, in that the patterns of spontaneous neural activities is independent of modalities of sensory input, therefore providing substantial information regarding the central mechanism of pED. Our previous study reported the altered baseline activity in right anterior insula (aINS) in pED patients. Also, the insula is a pivotal region in sexual behavior, which is suggested to be able to directly mediate erection. Therefore, the current study employed resting-state fMRI to examine alterations in functional connectivity (FC) of the aINS comparing pED patients with matched control subjects. After rigorous participant inclusion procedure, 27 pED patients and 27 healthy male controls were enrolled. Our results elucidated the disrupted homogeneity within the right aINS and aberrant connection patterns between the right aINS and the right dorsolateral prefrontal cortex (dlPFC), as well as the right aINS and the right temporoparietal junction (TPJ) respectively in pED group, as compared with the healthy controls. In conclusion, our results demonstrated the aberrant insula-centered FC in pED, which may be related to the abnormal representation of internal bodily state or needs in pED patients and thus further affect the inhibitory control in the sexual context. We hope that these findings may shed new light on the understanding of the central mechanism of pED.
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