ReviewClujul medical (1957)2017
The determination factors of left-right asymmetry disorders- a short review.
Review in Clujul medical (1957), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Structural and functional characterization of DNAH5 variants in a Portuguese family with primary ciliary dyskinesia.Journal of assisted reproduction and genetics · 2026Article
- Article
- Video thoracoscopic surgery for lung cancer in situs inversus totalis: a case report.Journal of cardiothoracic surgery · 2026Article
- Article
- From Petri Dish to Primitive Heart: How IVF Alters Early Cardiac Gene Networks and Epigenetic Landscapes.Biomedicines · 2025Review
- Unilateral Lung Agenesis and Left Isomerism in a Neonate: A Case Report of Multi-system Anomalies.Cureus · 2025Article
- ModelingJournal of the American Heart Association · 2025Article
- Laparoscopic Cholecystectomy in Situs Inversus Totalis: A Case Report.Clinical case reports · 2025Article
- Clinical features and genetic spectrum of children with primary ciliary dyskinesia in central China: a referral center retrospective analysis.Frontiers in pharmacology · 2025Article
- Hypoparathyroidism with situs inversus totalis: A case report.World journal of radiology · 2024Article
- A case report and anesthetic implications of situs inversus totalis in video-assisted thoracoscopic pulmonary resection.Annals of medicine and surgery (2012) · 2024Article
- Article
- Identification of novel compound heterozygous variants in theFrontiers in molecular biosciences · 2023Article
- LOF variants identifying candidate genes of laterality defects patients with congenital heart disease.PLoS genetics · 2022Article
- Single Cell Transcriptomics of Ependymal Cells Across Age, Region and Species Reveals Cilia-Related and Metal Ion Regulatory Roles as Major Conserved Ependymal Cell Functions.Frontiers in cellular neuroscience · 2021Article
- Mechanical Forces Regulate Asymmetric Vascular Cell Alignment.Biophysical journal · 2020Article
- Dioxin and AHR impairs mesoderm gene expression and cardiac differentiation in human embryonic stem cells.The Science of the total environment · 2019Article
- Situs Inversus Totalis.Academic forensic pathology · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laterality defects in humans, situs inversus and heterotaxy, are rare disorders, with an incidence of 1:8000 to 1:10 000 in the general population, and a multifactorial etiology. It has been proved that 1.44/10 000 of all cardiac problems are associated with malformations of left-right asymmetry and heterotaxy accounts for 3% of all congenital heart defects. It is considered that defects of situs appear due to genetic and environmental factors. Also, there is evidence that the ciliopathies (defects of structure or function) are involved in development abnormalities. Over 100 genes have been reported to be involved in left-right patterning in model organisms, but only a few are likely to candidate for left-right asymmetry defects in humans. Left-right asymmetry disorders are genetically heterogeneous and have variable manifestations (from asymptomatic to serious clinical problems). The discovery of the right mechanism of left-right development will help explain the clinical complexity and may contribute to a therapy of these disorders.
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