ArticleScientific reports2017
Anti-Aging Potentials of Methylene Blue for Human Skin Longevity.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 109 citations in OpenAlex.
- Skin Rejuvenation Efficacy and Safety Evaluation ofBiomolecules · 2024Trial
- [Research progress on the mechanism of mitochondrial dynamics in diabetic foot ulcers and its related intervention strategies].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Review
- Article
- Methylene blue restores NADJournal of orthopaedic translation · 2026Article
- Wild-Type Scandinavian Planarian-Derived Extracellular Vesicles Accelerate Skin Wound Healing in Burn and Mechanical Injuries.ACS omega · 2026Article
- Mitochondrial dysfunction in cellular senescence: a bridge to neurodegenerative disease.npj aging · 2025Review
- In Vitro Skin Models as Non-Animal Methods for Dermal Drug Development and Safety Assessment.Pharmaceutics · 2025Review
- Interface Catalysts of In Situ-Grown TiOMolecules (Basel, Switzerland) · 2025Article
- Effects of a single application of hydrolyzed fish collagen on dermal protein expression and tissue architecture in human skin models.Scientific reports · 2025Article
- Modified starch as a new co-excipient in hydrophilic gels for prolonged drug delivery.Scientific reports · 2025Article
- Targeting the Electron Transport System for Enhanced Longevity.Biomolecules · 2025Review
- Parishin Alleviates Pulmonary Fibrosis by Reducing CD38 Levels in Naturally Aging Mice.Rejuvenation research · 2025Article
- An Overview of Potential Applications of Environmentally Friendly Hybrid Polymeric Materials.Polymers · 2025Review
- Study on the Skincare Effects of Red Rice Fermented byMolecules (Basel, Switzerland) · 2024Article
- Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging.Aging · 2024Article
- Effect of Selected Antioxidants on the In Vitro Aging of Human Fibroblasts.International journal of molecular sciences · 2024Article
- Recent insights into catechins-rich Assam tea extract for photoaging and senescent ageing.Scientific reports · 2024Article
- Krill oil: nutraceutical potential in skin health and disease.Frontiers in nutrition · 2024Review
- Evaluation of topical methylene blue nanoemulsion for wound healing in diabetic mice.Pharmaceutical biology · 2023Article
- Effect of Low Concentration of Nitroxides on SH-SY5Y Cells Transfected with the Tau Protein.International journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Oxidative stress is the major cause of skin aging that includes wrinkles, pigmentation, and weakened wound healing ability. Application of antioxidants in skin care is well accepted as an effective approach to delay the skin aging process. Methylene blue (MB), a traditional mitochondrial-targeting antioxidant, showed a potent ROS scavenging efficacy in cultured human skin fibroblasts derived from healthy donors and from patients with progeria, a genetic premature aging disease. In comparison with other widely used general and mitochondrial-targeting antioxidants, we found that MB was more effective in stimulating skin fibroblast proliferation and delaying cellular senescence. The skin irritation test, performed on an in vitro reconstructed 3D human skin model, indicated that MB was safe for long-term use, and did not cause irritation even at high concentrations. Application of MB to this 3D skin model further demonstrated that MB improved skin viability, promoted wound healing and increased skin hydration and dermis thickness. Gene expression analysis showed that MB treatment altered the expression of a subset of extracellular matrix proteins in the skin, including upregulation of elastin and collagen 2A1, two essential components for healthy skin. Altogether, our study suggests that MB has a great potential for skin care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.