Evidence map›Paper›PMID 28559391›Full record

ReviewHypertension (Dallas, Tex. : 1979)2017

How Is the Brain Renin-Angiotensin System Regulated?

Pablo Nakagawa, Curt D Sigmund

Abstract readReview
In one paragraph

Review in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Brain and hypertension: from sympathetic outflow to brain-focused blood pressure management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. The Contribution of the Renin-Angiotensin System to Alzheimer's Disease.Current topics in behavioral neurosciences · 2025
    Review
  8. Renin Is Essential for Angiotensin II Formation in the Brain.Journal of the American Heart Association · 2024
    Article
  9. Review
  10. Article
  11. Contributions of neuroimaging to the knowledge of the relationship between arterial hypertension and cognitive decline.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pablo NakagawaFrom the Department of Pharmacology, UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City.
Curt D SigmundFrom the Department of Pharmacology, UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City. curt-sigmund@uiowa.edu.

Funding

Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2M
Role of PPARG the PPARG Target Gene RBP7 in the EndotheliumR01HL131689 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2016 to 2018
$1.9M
Hypertension: Role of Smooth Muscle Cullin-3 and the CRL3 ComplexR01HL125603 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2015 to 2018
$1.7M
NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL125603NHLBI NIH HHS R01 HL131689
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Angiotensin IIAngiotensinogenAnimalsBlood PressureBrainHumansPeptidyl-Dipeptidase AProrenin ReceptorReceptors, Cell SurfaceReninRenin-Angiotensin SystemVacuolar Proton-Translocating ATPasesAngiotensin IIAngiotensinogenATP6AP2 protein, humanPeptidyl-Dipeptidase AProrenin ReceptorReceptors, Cell SurfaceReninVacuolar Proton-Translocating ATPases

Identifiers

PMID28559391
PMCPMC5511499

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.