ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
A Role for Auditory Corticothalamic Feedback in the Perception of Complex Sounds.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network.Nature reviews. Neuroscience · 2026Review
- Cortical representation of pitch perception in mice.Communications biology · 2026Article
- Review
- Tonotopic organization in the basal region of the ventromedial nucleus of the thalamus revealed by fiber photometry recording.Neurophotonics · 2026Article
- Layer-specific cortical dynamics during transitions from error monitoring to decision execution in reversal learning.Communications biology · 2025Article
- Synaptic Properties of Layer 6 Auditory Corticothalamic Inputs in Normal Hearing and Noise-Induced Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems.iScience · 2025Article
- Subcortical origin of nonlinear sound encoding in auditory cortex.Current biology : CB · 2024Article
- The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Inhibiting presynaptic calcium channel motility in the auditory cortex suppresses synchronized input processing.Frontiers in cellular neuroscience · 2024Article
- Cortical evoked activity is modulated by the sleep state in a ferret model of tinnitus. A cross-case study.PloS one · 2024Article
- Organization of orbitofrontal-auditory pathways in the Mongolian gerbil.The Journal of comparative neurology · 2023Article
- Review
- Selective corticofugal modulation on sound processing in auditory thalamus of awake marmosets.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The psychotomimetic ketamine disrupts the transfer of late sensory information in the corticothalamic network.The European journal of neuroscience · 2023Article
- Non-sensory Influences on Auditory Learning and Plasticity.Journal of the Association for Research in Otolaryngology : JARO · 2022Review
- Selective Interruption of Auditory Interhemispheric Cross Talk Impairs Discrimination Learning of Frequency-Modulated Tone Direction But Not Gap Detection and Discrimination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- What can we learn from inactivation studies? Lessons from auditory cortex.Trends in neurosciences · 2022Review
- Rabbits use both spectral and temporal cues to discriminate the fundamental frequency of harmonic complexes with missing fundamentals.Journal of neurophysiology · 2022Article
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6 authors.
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Abstract
Feedback signals from the primary auditory cortex (A1) can shape the receptive field properties of neurons in the ventral division of the medial geniculate body (MGBv). However, the behavioral significance of corticothalamic modulation is unknown. The aim of this study was to elucidate the role of this descending pathway in the perception of complex sounds. We tested the ability of adult female ferrets to detect the presence of a mistuned harmonic in a complex tone using a positive conditioned go/no-go behavioral paradigm before and after the input from layer VI in A1 to MGBv was bilaterally and selectively eliminated using chromophore-targeted laser photolysis. MGBv neurons were identified by their short latencies and sharp tuning curves. They responded robustly to harmonic complex tones and exhibited an increase in firing rate and temporal pattern changes when one frequency component in the complex tone was mistuned. Injections of fluorescent microbeads conjugated with a light-sensitive chromophore were made in MGBv, and, following retrograde transport to the cortical cell bodies, apoptosis was induced by infrared laser illumination of A1. This resulted in a selective loss of ∼60% of layer VI A1-MGBv neurons. After the lesion, mistuning detection was impaired, as indicated by decreased
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