Evidence map›Paper›PMID 28559264›Full record

ArticleAntimicrobial agents and chemotherapy2017

Synergistic Activity between Statins and Bisphosphonates against Acute Experimental Toxoplasmosis.

Zhu-Hong Li, Catherine Li, Sergio H Szajnman, Juan B Rodriguez, Silvia N J Moreno

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  7. Inhibition ofFrontiers in cellular and infection microbiology · 2022
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  8. Anti-Biomedicines · 2021
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  12. Interaction of apigenin-7-O-glucoside with pyrimethamine againstJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Zhu-Hong LiCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, USA.
Catherine LiCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, USA.
Sergio H SzajnmanDepartamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
Juan B RodriguezDepartamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
Silvia N J MorenoCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, USA smoreno@uga.edu.
University of Georgia · USConsejo Nacional de Investigaciones Científicas y Técnicas · ARFundación Ciencias Exactas y Naturales · AR

Funding

Targeting Host and Apicomplexan Isoprenoid PathwaysR33AI102254 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2014 to 2016
$1.3M
Targeting Host and Apicomplexan Isoprenoid PathwaysR21AI102254 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2012 to 2013
$408k
NIAID NIH HHS R21 AI102254NIAID NIH HHS R33 AI102254
6 · The paper itself

Abstract

Bisphosphonates are widely used for the treatment of bone disorders. These drugs also inhibit the growth of a variety of protozoan parasites, such as

Indexed as

Acyl Coenzyme AAnimalsAntiprotozoal AgentsAtorvastatinCell LineDiphosphonatesGeranylgeranyl-Diphosphate GeranylgeranyltransferaseGeranyltranstransferaseHydroxymethylglutaryl-CoA Reductase InhibitorsHydroxymethylglutaryl CoA ReductasesImidazolesMicePolyisoprenyl PhosphatesSesquiterpenesToxoplasmaToxoplasmosis1-((N-heptylthio)ethyl)-1,1-bisphosphonate3-hydroxy-3-methylglutaryl-coenzyme AAcyl Coenzyme AAntiprotozoal AgentsAtorvastatinDiphosphonatesfarnesyl pyrophosphateGeranylgeranyl-Diphosphate GeranylgeranyltransferaseGeranyltranstransferaseHydroxymethylglutaryl-CoA Reductase InhibitorsHydroxymethylglutaryl CoA ReductasesImidazolesPolyisoprenyl PhosphatesSesquiterpenesZoledronic AcidbisphosphonateisoprenoidsstatinssynergyToxoplasma gondii

Identifiers

PMID28559264
PMCPMC5527628
OpenAlexW2620471336

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.