Evidence map›Paper›PMID 28559261›Full record

ArticleAntimicrobial agents and chemotherapy2017

The Fluorocycline TP-271 Is Efficacious in Models of Aerosolized Francisella tularensis SCHU S4 Infection in BALB/c Mice and Cynomolgus Macaques.

Trudy H Grossman, Michael S Anderson, David Christ, Melanie Gooldy, Lisa N Henning, Henry S Heine, M Victoria Kindt, Winston Lin, Kaylyn Siefkas-Patterson, Anne K Radcliff and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Eravacycline: From broad-spectrum coverage to novel clinical applications.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026
    Review
  3. Article
  4. Animal modelling with theMicrobiology (Reading, England) · 2025
    Article
  5. Review
  6. Omadacycline is activeAntimicrobial agents and chemotherapy · 2024
    Article
  7. Non-vaccinal prophylaxis of tularemia.Frontiers in microbiology · 2024
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Trudy H GrossmanTetraphase Pharmaceuticals, Inc., Watertown, Massachusetts, USA tgrossman@yahoo.com.
Michael S AndersonBattelle, Columbus, Ohio, USA.
David ChristSNC Partners, LLC, Newark, Delaware, USA.
Melanie GooldyCUBRC, Inc., Buffalo, New York, USA.
Lisa N HenningBattelle, Columbus, Ohio, USA.
Henry S HeineUnited States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
M Victoria KindtPathways Toxicology Consulting, LLC, Lahaska, Pennsylvania, USA.
Winston LinIIT Research Institute, Chicago, Illinois, USA.
Kaylyn Siefkas-PattersonIIT Research Institute, Chicago, Illinois, USA.
Anne K RadcliffCUBRC, Inc., Buffalo, New York, USA.
Vincent H TamUniversity of Houston College of Pharmacy, Houston, Texas, USA.
Joyce A SutcliffeTetraphase Pharmaceuticals, Inc., Watertown, Massachusetts, USA.
Battelle · USCalspan-University of Buffalo Research Center · USIIT Research Institute · USTetraphase Pharmaceuticals (United States) · USPathways Behavioral Services · USUnited States Army Medical Research Institute of Infectious Diseases · USUniversity of Houston · US

Funding

Development of TP-217 as a highly efficacious, broad-spectrum antibiotic for theR01AI093484 · NIAID · CUBRC, INC. · PI GROSSMAN, TRUDY HOPE, RADCLIFF, ANNE KATHLEEN · 2011 to 2015
$2.8M
NIAID NIH HHS HHSN272201100028CNIAID NIH HHS R01 AI093484
6 · The paper itself

Abstract

TP-271 is a novel, fully synthetic fluorocycline in development for complicated bacterial respiratory infections. TP-271 was active

Indexed as

AnimalsAnti-Bacterial AgentsDisease Models, AnimalFemaleFrancisella tularensisMacaca fascicularisMaleMiceMice, Inbred BALB CMicrobial Sensitivity TestsRespiratory Tract InfectionsTetracyclinesTularemiaAnti-Bacterial AgentsTetracyclinesTP-271fluorocyclineFrancisella tularensisTP-271tularemia

Identifiers

PMID28559261
PMCPMC5527625
OpenAlexW2617417386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.