Evidence map›Paper›PMID 28559022›Full record

ReviewOral oncology2017

Improving accuracy of RNA-based diagnosis and prognosis of oral cancer by using noninvasive methods.

Guy R Adami, Jessica L Tang, Michael R Markiewicz

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oral oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Guy R AdamiDepartment of Oral Medicine and Oral Diagnostics, College of Dentistry, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60610, USA; Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60610, USA. Electronic address: gadami@uic.edu.
Jessica L TangDepartment of Oral Medicine and Oral Diagnostics, College of Dentistry, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60610, USA; Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60610, USA.
Michael R MarkiewiczDepartment of Oral and Maxillofacial Surgery, College of Dentistry, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60610, USA; Division of Dentistry, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
University of Illinois Chicago · US

Funding

RNA from Brush Cytology to Detect Squamous Cell CarcinomaR21CA139137 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SCHWARTZ, JOEL L · 2010 to 2011
$371k
RNA from Brush Cytology to Identify Aggressive Squamous Cell CarcinomaR03CA150076 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ADAMI, GUY RICHARD, SCHWARTZ, JOEL L · 2012 to 2013
$155k
NCI NIH HHS R03 CA150076NCI NIH HHS R21 CA139137
6 · The paper itself

Abstract

RNA-based diagnosis and prognosis of squamous cell carcinoma has been slow to come to the clinic. Improvements in RNA measurement, statistical evaluation, and sample preservation, along with increased sample numbers, have not made these methods reproducible enough to be used clinically. We propose that, in the case of squamous cell carcinoma of the oral cavity, a chief source of variability is sample dissection, which leads to variable amounts of stroma mixed in with tumor epithelium. This heterogeneity of the samples, which requires great care to avoid, makes it difficult to see changes in RNA levels specific to tumor cells. An evaluation of the data suggests that, paradoxically, brush biopsy samples of oral lesions may provide a more reproducible method than surgical acquisition of samples for miRNA measurement. The evidence also indicates that body fluid samples can show similar changes in miRNAs with oral squamous cell carcinoma (OSCC) as those seen in tumor brush biopsy samples - suggesting much of the miRNA in these samples is coming from the same source: tumor epithelium. We conclude that brush biopsy or body fluid samples may be superior to surgical samples in allowing miRNA-based diagnosis and prognosis of OSCC in that they feature a rapid method to obtain homogeneous tumor cells and/or RNA.

Indexed as

BiopsyBody FluidsCarcinoma, Squamous CellHumansMolecular Diagnostic TechniquesMouth NeoplasmsPrognosisRNA, NeoplasmSensitivity and SpecificityRNA, NeoplasmBody fluidBrush biopsyCancer detectionHead and neck cancermiRNAPrognosisRNASalivaTumor markers

Identifiers

PMID28559022
PMCPMC5497764
OpenAlexW2606866150

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.