ArticleJournal of chromatography. A2017
Cold-induced aqueous acetonitrile phase separation: A salt-free way to begin quick, easy, cheap, effective, rugged, safe.
Article in Journal of chromatography. A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- [Fast determination of per- and polyfluoroalkyl substances in human serum by cold-induced phase separation coupled with liquid chromatography-tandem mass spectrometry].Se pu = Chinese journal of chromatography · 2025Article
- SWIEET-a salt-free alternative to QuEChERS.Analytical and bioanalytical chemistry · 2024Article
- Fast determination of organophosphate esters and their metabolites in human matrices by a straightforward cold-induced strategy coupled with HPLC-MS/MS.Analytical and bioanalytical chemistry · 2024Article
- Multiplexing Iduronate-2-Sulphatase (MPS-II) into a 7-Plex Lysosomal Storage Disorder MS/MS Assay Using Cold-Induced Phase Separation.International journal of neonatal screening · 2023Article
- The Zooxanthellate Jellyfish HolobiontMarine drugs · 2023Article
- Cold-induced phase separation for the simple and reliable extraction of sex hormones for subsequent LC-MS/MS analysis.Journal of lipid research · 2022Article
- Green Chemistry Preservation and Extraction of Biospecimens for Multi-omic Analyses.Methods in molecular biology (Clifton, N.J.)Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Cooling a 1:1 (v/v) solution of acetonitrile and water at -16° C is known to result in two clear phases. We will refer to this event as "cold-induced aqueous acetonitrile phase separation (CIPS)". On a molar basis, acetonitrile is 71.7% and 13.6% in the upper and lower phases, respectively, in our study. The phase separation proceeds as a descending cloud of microdroplets. At the convenient temperature (typical freezer) employed here the lower phase is rather resistant to solidification, although it emerges from the freezer as a solid if various insoluble matter is present at the outset. In a preliminary way, we replaced the initial (salting-out) step of a representative QuEChERS procedure with CIPS, applying this modified procedure ("CIPS-QuEChERS") to a homogenate of salmon (and partly to beef). Three phases resulted, where only the upper, acetonitrile-rich phase is a liquid (that is completely clear). The middle phase comprises ice and precipitated lipids, while the lower phase is the residual matrix of undissolved salmon or meat. Treating the upper phase from salmon, after isolation, with anhydrous MgSO
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