Trial reportJournal of neuroengineering and rehabilitation2017
Effects of exercise on brain activity during walking in older adults: a randomized controlled trial.
Trial report in Journal of neuroengineering and rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Visual attention and postural stability among older adults participating in health-enhancing physical activity: a systematic review.Frontiers in network physiology · 2026Pooled it
- Brain function effects of exercise interventions for cognitive decline: a systematic review and meta-analysis.Frontiers in neuroscience · 2023Pooled it
- Effects of creative expression therapy for older adults with mild cognitive impairment at risk of Alzheimer's disease: a randomized controlled clinical trial.Clinical interventions in aging · 2018Trial
- Effects of Resistance Exercise Training on Cognitive Function and Physical Performance in Cognitive Frailty: A Randomized Controlled Trial.The journal of nutrition, health & aging · 2018Trial
- The relationship between physical activity and mental health in middle-aged and older Chinese adults: a moderated mediation and cross-lagged model.Frontiers in psychology · 2026Article
- Associations Between Makeup Use and Physical, Cognitive, and Psychological Functions in Community-Dwelling Older Women.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Mechanisms of interventions targeting modifiable factors for dementia risk reduction.Molecular neurodegeneration · 2025Review
- Process validation and preclinical development of a new PET cerebral blood flow tracer [EJNMMI radiopharmacy and chemistry · 2024Article
- The Effect of Aerobic Exercise in Neuroplasticity, Learning, and Cognition: A Systematic Review.Cureus · 2024Review
- Endogenous Opioids and Exercise-Related Hypoalgesia: Modern Models, Measurement, and Mechanisms of Action.Advances in neurobiology · 2024Article
- Prediction of voluntary movements of the upper extremities by resting state-brain regional glucose metabolism in patients with chronic severe brain injury: A pilot study.Human brain mapping · 2023Article
- Effects of Nordic walking in Alzheimer's disease: A single-blind randomized controlled clinical trial.Heliyon · 2023Article
- Resistance Training Increases White Matter Density in Frail Elderly Women.Journal of clinical medicine · 2023Article
- Relationship between temporal dynamics of intrinsic brain activity and motor function remodeling in patients with acute BGIS.Frontiers in neuroscience · 2023Article
- Gait Characteristics of Dynapenia, Sarcopenia, and Presarcopenia in Community-Dwelling Japanese Older Women: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2022Article
- Development of a Combined Exercise and Cognitive Stimulation Intervention for People with Mild Cognitive Impairment-Designing the MEMO_MOVE PROGRAM.International journal of environmental research and public health · 2022Review
- Brain Mapping the Effects of Chronic Aerobic Exercise in the Rat Brain Using FDG PET.Journal of personalized medicine · 2022Article
- State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.Comprehensive Physiology · 2022Article
- Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice.Journal of neuroinflammation · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysical activity may preserve neuronal plasticity, increase synapse formation, and cause the release of hormonal factors that promote neurogenesis and neuronal function. Previous studies have reported enhanced neurocognitive function following exercise training. However, the specific cortical regions activated during exercise training remain largely undefined. In this study, we quantitatively and objectively evaluated the effects of exercise on brain activity during walking in healthy older adults.
methodsA total of 24 elderly women (75-83 years old) were randomly allocated to either an intervention group or a control group. Those in the intervention group attended 3 months of biweekly 90-min sessions focused on aerobic exercise, strength training, and physical therapy. We monitored changes in regional cerebral glucose metabolism during walking in both groups using positron emission tomography (PET) and [
resultsAll subjects completed the 3-month experiment and the adherence to the exercise program was 100%. Compared with the control group, the intervention group showed a significantly greater step length in the right foot after 3 months of physical activity. The FDG-PET assessment revealed a significant post-intervention increase in regional glucose metabolism in the left posterior entorhinal cortex, left superior temporal gyrus, and right superior temporopolar area in the intervention group. Interestingly, the control group showed a relative increase in regional glucose metabolism in the left premotor and supplemental motor areas, left and right somatosensory association cortex, and right primary visual cortex after the 3-month period. We found no significant differences in FDG uptake between the intervention and control groups before vs. after the intervention.
conclusionExercise training increased activity in specific brain regions, such as the precuneus and entorhinal cortices, which play an important role in episodic and spatial memory. Further investigation is required to confirm whether alterations in glucose metabolism within these regions during walking directly promote physical and cognitive performance.
trial registrationUMIN-CTR ( UMIN000021829 ). Retrospectively registered 10 April 2016.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.