ArticleBMC genomics2017
The Cyprinodon variegatus genome reveals gene expression changes underlying differences in skull morphology among closely related species.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Craniofacial-specific transcriptomics uncovers novel genes underlying jaw divergence in dietary specialist pupfishes.Genetics · 2025Article
- A Class of Allopolyploidy Showing High Duplicate Retention and Continued Homoeologous Exchanges.Genome biology and evolution · 2025Article
- Phenotypic covariation predicts diversification in an adaptive radiation of pupfishes.Ecology and evolution · 2024Article
- Important Role of the Ihh Signaling Pathway in Initiating Early Cranial Remodeling and Morphological Specialization inAnimals : an open access journal from MDPI · 2023Article
- Jaw size variation is associated with a novel craniofacial function for galanin receptor 2 in an adaptive radiation of pupfishes.Proceedings. Biological sciences · 2023Article
- Jaw size variation is associated with a novel craniofacial function for galanin receptor 2 in an adaptive radiation of pupfishes.bioRxiv : the preprint server for biology · 2023Article
- Extensive Adaptive Variation in Gene Expression within and between Closely Related Horseshoe Bats (Chiroptera,Animals : an open access journal from MDPI · 2022Article
- Few Fixed Variants between Trophic Specialist Pupfish Species Reveal Candidate Cis-Regulatory Alleles Underlying Rapid Craniofacial Divergence.Molecular biology and evolution · 2021Article
- Ecological divergence in sympatry causes gene misexpression in hybrids.Molecular ecology · 2020Article
- Oral shelling within an adaptive radiation of pupfishes: Testing the adaptive function of a novel nasal protrusion and behavioural preference.Journal of fish biology · 2020Article
- Differences in Cell Proliferation and Craniofacial Phenotype of Closely Related Species in the Pupfish Genus Cyprinodon.The Journal of heredity · 2020Article
- Rapid adaptive evolution of scale-eating kinematics to a novel ecological niche.The Journal of experimental biology · 2020Article
- Hybrid gene misregulation in multiple developing tissues within a recent adaptive radiation of Cyprinodon pupfishes.PloS one · 2019Article
- How to Investigate the Origins of Novelty: Insights Gained from Genetic, Behavioral, and Fitness Perspectives.Integrative organismal biology (Oxford, England) · 2019Article
- Parallel evolution of gene expression between trophic specialists despite divergent genotypes and morphologies.Evolution letters · 2018Article
- Building trophic specializations that result in substantial niche partitioning within a young adaptive radiation.Journal of anatomy · 2018Article
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- The behavioral origins of novelty: did increased aggression lead to scale-eating in pupfishes?Behavioral ecology : official journal of the International Society for Behavioral EcologyArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundUnderstanding the genetic and developmental origins of phenotypic novelty is central to the study of biological diversity. In this study we identify modifications to the expression of genes at four developmental stages that may underlie jaw morphological differences among three closely related species of pupfish (genus Cyprinodon) from San Salvador Island, Bahamas. Pupfishes on San Salvador Island are trophically differentiated and include two endemic species that have evolved jaw morphologies unlike that of any other species in the genus Cyprinodon.
resultsWe find that gene expression differs significantly across recently diverged species of pupfish. Genes such as Bmp4 and calmodulin, previously implicated in jaw diversification in African cichlid fishes and Galapagos finches, were not found to be differentially expressed among species of pupfish. Instead we find multiple growth factors and cytokine/chemokine genes to be differentially expressed among these pupfish taxa. These include both genes and pathways known to affect craniofacial development, such as Wnt signaling, as well as novel genes and pathways not previously implicated in craniofacial development. These data highlight both shared and potentially unique sources of jaw diversity in pupfish and those identified in other evolutionary model systems such as Galapagos finches and African cichlids.
conclusionsWe identify modifications to the expression of genes involved in Wnt signaling, Igf signaling, and the inflammation response as promising avenues for future research. Our project provides insight into the magnitude of gene expression changes contributing to the evolution of morphological novelties, such as jaw structure, in recently diverged pupfish species.
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