ArticleDrug and alcohol dependence2017
The effects of social contact on cocaine intake in female rats.
Article in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Preclinical abuse potential testing using behavioral economics and drug self-administration demand-curve analysis: A strategy to improve resolution of drug stratification for regulatory control.Pharmacological reviews · 2026Review
- Social context in renewal of cocaine and fentanyl seeking: role of peer presence versus peer absence.Psychopharmacology · 2026Article
- Social enhancement of cocaine intake: behavioral mechanisms and role of reinforcing stimulus.Psychopharmacology · 2026Article
- The impact of sex, species, environmental context, and alternative reinforcers in animal models of cocaine use disorders.Pharmacology, biochemistry, and behavior · 2025Review
- Mechanistic and translational insights from preclinical cocaine choice procedures on the economic substitutability of cocaine and nondrug reinforcers.Neuroscience and biobehavioral reviews · 2025Review
- The positive reinforcing effects of cocaine and opposite-sex social contact: roles of biological sex and estrus.Psychopharmacology · 2025Article
- Response-contingent cocaine increases the reinforcing effectiveness of social contact.Experimental and clinical psychopharmacology · 2024Article
- Social influence and the likelihood of using cannabis: Role of source physical attractiveness.Experimental and clinical psychopharmacology · 2023Article
- Role of social context in addiction etiology and recovery.Pharmacology, biochemistry, and behavior · 2023Review
- Demand and cross-price elasticity of cocaine and social contact in a free-operant procedure of nonexclusive choice.Pharmacology, biochemistry, and behavior · 2023Article
- The Protective Effect of Social Reward on Opioid and Psychostimulant Reward and Relapse: Behavior, Pharmacology, and Brain Regions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- Lack of evidence for positive reinforcing and prosocial effects of MDMA in pair-housed male and female rats.European journal of pharmacology · 2021Article
- Social Contact Reinforces Cocaine Self-Administration in Young Adult Male Rats: The Role of Social Reinforcement in Vulnerability to Drug Use.Frontiers in behavioral neuroscience · 2021Article
- Enhancement of Drug Seeking Following Drug Taking in a Sexual Context Requires Anterior Cingulate Cortex Activity in Male Rats.Frontiers in behavioral neuroscience · 2020Article
- The influence of sex and estrous cyclicity on cocaine and remifentanil demand in rats.Addiction biology · 2020Article
- Cues play a critical role in estrous cycle-dependent enhancement of cocaine reinforcement.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Drug-taking in a socio-sexual context enhances vulnerability for addiction in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Considering the context: social factors in responses to drugs in humans.Psychopharmacology · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundStudies conducted in male rats report that social contact can either facilitate or inhibit drug intake depending on the behavior of social partners. The purpose of the present study was to: (1) examine the effects of social contact on cocaine intake in female rats, (2) examine the behavioral mechanisms by which social contact influences cocaine intake, and (3) examine whether the estrous cycle moderates the effects of social contact on cocaine intake.
methodsFemale rats were assigned to either isolated or pair-housed conditions in which a social partner either had access to cocaine (cocaine partner) or did not have access to cocaine (abstinent partner). Pair-housed rats were tested in custom-built operant conditioning chambers that allowed both rats to be tested simultaneously in the same chamber.
resultsRats housed with a cocaine partner self-administered more cocaine than isolated rats and rats housed with an abstinent partner. A behavioral economic analysis indicated that these differences were driven by a greater intensity of cocaine demand (i.e., greater intake at lower unit prices) in rats housed with a cocaine partner. Multivariate modeling revealed that the estrous cycle did not moderate the effects of social contact on cocaine intake.
conclusionsThese findings indicate that: (1) social contact influences cocaine self-administration in females in a manner similar to that reported in males, (2) these effects are due to differences in the effects of social contact on the intensity of cocaine demand, and (3) these effects are consistent across all phases of the estrous cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.