Evidence map›Paper›PMID 28558199›Full record

ArticleBiochemistry2017

Global Kinetic Mechanism of Microsomal Glutathione Transferase 1 and Insights into Dynamic Enzyme Activation.

Linda Spahiu, Johan Ålander, Astrid Ottosson-Wadlund, Richard Svensson, Carina Lehmer, Richard N Armstrong, Ralf Morgenstern

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Linda SpahiuInstitute of Environmental Medicine, Karolinska Institutet , SE-171 77 Stockholm, Sweden.
Johan ÅlanderInstitute of Environmental Medicine, Karolinska Institutet , SE-171 77 Stockholm, Sweden.
Astrid Ottosson-WadlundInstitute of Environmental Medicine, Karolinska Institutet , SE-171 77 Stockholm, Sweden.
Richard SvenssonUppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University , 753 12 Uppsala, Sweden.
Carina LehmerInstitute of Environmental Medicine, Karolinska Institutet , SE-171 77 Stockholm, Sweden.
Richard N ArmstrongDepartments of Biochemistry and Chemistry, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-0146, United States.
Ralf MorgensternInstitute of Environmental Medicine, Karolinska Institutet , SE-171 77 Stockholm, Sweden.ORCID 0000-0001-9094-0554

Funding

MECHANISM OF ACTION OF GLUTATHIONE S-TRANSFERASER01GM030910 · NIGMS · VANDERBILT UNIVERSITY · PI SANDERS, CHARLES R · 1985 to 2016
$4.7M
NIGMS NIH HHS R01 GM030910
6 · The paper itself

Abstract

Microsomal glutathione transferase 1 (MGST1) has a unique ability to be activated, ≤30-fold, by modification with sulfhydryl reagents. MGST1 exhibits one-third-of-the-sites reactivity toward glutathione and hence heterogeneous binding to different active sites in the homotrimer. Limited turnover stopped-flow kinetic measurements of the activated enzyme allowed us to more accurately determine the K

Indexed as

BiocatalysisEnzyme ActivationGlutathione TransferaseHumansKineticsModels, MolecularMolecular StructureGlutathione Transferasemicrosomal glutathione S-transferase-I

Identifiers

PMID28558199
PMCPMC5954419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.