Evidence map›Paper›PMID 28558078›Full record

ArticleArquivos brasileiros de cardiologia2016

Testosterone and Voluntary Exercise, Alone or Together Increase Cardiac Activation of AKT and ERK1/2 in Diabetic Rats.

Leila Chodari, Mustafa Mohammadi, Gisou Mohaddes, Mohammad Reza Alipour, Vajiheh Ghorbanzade, Hassan Dariushnejad, Shima Mohammadi

Open access · diamondAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Arquivos brasileiros de cardiologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Leila ChodariDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mustafa MohammadiDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Gisou MohaddesNeuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad Reza AlipourDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Vajiheh GhorbanzadeDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Hassan DariushnejadDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Shima MohammadiDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Tabriz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImpaired angiogenesis in cardiac tissue is a major complication of diabetes. Protein kinase B (AKT) and extracellular signal regulated kinase (ERK) signaling pathways play important role during capillary-like network formation in angiogenesis process.

objectivesTo determine the effects of testosterone and voluntary exercise on levels of vascularity, phosphorylated Akt (P- AKT) and phosphorylated ERK (P-ERK) in heart tissue of diabetic and castrated diabetic rats.

methodsType I diabetes was induced by i.p injection of 50 mg/kg of streptozotocin in animals. After 42 days of treatment with testosterone (2mg/kg/day) or voluntary exercise alone or in combination, heart tissue samples were collected and used for histological evaluation and determination of P-AKT and P-ERK levels by ELISA method.

resultsOur results showed that either testosterone or exercise increased capillarity, P-AKT, and P-ERK levels in the heart of diabetic rats. Treatment of diabetic rats with testosterone and exercise had a synergistic effect on capillarity, P-AKT, and P-ERK levels in heart. Furthermore, in the castrated diabetes group, capillarity, P-AKT, and P-ERK levels significantly decreased in the heart, whereas either testosterone treatment or exercise training reversed these effects. Also, simultaneous treatment of castrated diabetic rats with testosterone and exercise had an additive effect on P-AKT and P-ERK levels.

conclusionOur findings suggest that testosterone and exercise alone or together can increase angiogenesis in the heart of diabetic and castrated diabetic rats. The proangiogenesis effects of testosterone and exercise are associated with the enhanced activation of AKT and ERK1/2 in heart tissue.

Indexed as

AndrogensAnimalsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Enzyme-Linked Immunosorbent AssayExtracellular Signal-Regulated MAP KinasesHeartHormone Replacement TherapyMaleMyocardiumMyocytes, CardiacNeovascularization, PhysiologicPhysical Conditioning, AnimalProto-Oncogene Proteins c-aktRats, WistarReproducibility of ResultsAndrogensExtracellular Signal-Regulated MAP KinasesProto-Oncogene Proteins c-aktTestosterone

Identifiers

PMID28558078
PMCPMC5210457
OpenAlexW2548180486

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.