ArticlePloS one2017
The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- A meta-analysis of the association between inflammatory cytokine polymorphism and neonatal sepsis.PloS one · 2024Pooled it
- Association between innate immunity gene polymorphisms and neonatal sepsis development: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2022Pooled it
- [Recent research on gene polymorphisms and genetic susceptibility of neonatal sepsis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- The association between mannose binding lectin gene polymorphisms and the risk of neonatal sepsis: an updated meta-analysis.Heliyon · 2023Review
- Collectins and ficolins in neonatal health and disease.Frontiers in immunology · 2023Review
- Association Between Variants of the Mannose-Binding Lectin 2 Gene and Susceptibility to Sepsis in the Hainan Island.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Role ofDiagnostics (Basel, Switzerland) · 2022Article
- Gut Microbiota Disorder, Gut Epithelial and Blood-Brain Barrier Dysfunctions in Etiopathogenesis of Dementia: Molecular Mechanisms and Signaling Pathways.Neuromolecular medicine · 2019Review
- MBL2 gene polymorphisms in HHV-8 infection in people living with HIV/AIDS.Retrovirology · 2018Article
- Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants.Pediatric research · 2018Article
- Antimicrobial peptide LL-37 and recombinant human mannose-binding lectin express distinct age- and pathogen-specific antimicrobial activity in human newborn cord bloodF1000Research · 2018Article
- Mannose-binding lectin gene polymorphism and its effect on short term outcomes in preterm infants.Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesStudies on the influence of mannose-binding lectin (MBL) deficiency on infection susceptibility in preterm infants have yielded controversial results. We investigated the association of genotype-based MBL levels with outcome in very-low-birth weight infants (VLBWI).
methodsWe genotyped 3 genetic variants of MBL2 (rs1800450, rs1800451, rs5030737) in 6878 VLBWI. MBL plasma levels were categorized as normal (wild type, A/A), low (heterozygotes, A/O) or undetectable (homozygotes, O/O). Primary outcome was the effect of genotype-based MBL2 levels on blood-culture proven and clinical sepsis during primary stay in hospital. We also evaluated burden of infection within 24 months after discharge.
resultsWe found no association between MBL levels and sepsis risk in the whole cohort. Infants without measurable MBL levels born between 32 0/7 to 36 6/7 weeks of gestation, however, had a higher rate of Gram-negative sepsis than infants with normal or reduced MBL levels. In a follow-up investigation at 24 months (n = 1070 infants), infants without measurable MBL levels suffered more frequently from stomatitis and urinary tract infection.
conclusionsIn a large cohort of VLBWI MBL2 deficiency had no major impact on infection risk unless children were born between 32 0/7 and 36 6/7 weeks of gestation.
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