ArticlePloS one2017
Preparation and characterization of a novel silicon-modified nanobubble.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- General Characteristics of Microbubble-Adenovirus Vectors Carrying Genes.Cellular and molecular bioengineering · 2021Article
- Stability of Engineered Micro or Nanobubbles for Biomedical Applications.Pharmaceutics · 2020Review
- The Optimized Fabrication of a Novel Nanobubble for Tumor Imaging.Frontiers in pharmacology · 2019Article
- A Novel Bimodal Imaging Agent Targeting HER2 Molecule of Breast Cancer.Journal of immunology research · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanobubbles (NBs) opened a new field of ultrasound imaging. There is still no practical method to control the diameter of bubbles. In this study, we developed a new method to control the size by incorporating of silicon hybrid lipids into the bubble membrane. The range of particle size of resulting NBs is between 523.02 ± 46.45 to 857.18 ± 82.90, smaller than the conventional microbubbles. The size of resulting NBs increased with the decrease in amount of silicon hybrid lipids, indicating the diameter of NBs can be regulated through modulating the ratio of silicon hybrid lipids in the bubble shell. Typical harmonic signals could be detected. The in vitro and in vivo ultrasound imaging experiments demonstrated these silicon-modified NBs had significantly improved ultrasound contrast enhancement abilities. Cytotoxicity assays revealed that these NBs had no obvious cytotoxicity to the 293 cell line at the tested bubble concentration. Our results showed that the novel NBs could use as nanoscale ultrasound contrast agents, providing the foundation for NBs in future applications including contrast-enhanced imaging and drug/gene delivery.
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Registered trials
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