ArticlePLoS biology2017
Local introduction and heterogeneous spatial spread of dengue-suppressing Wolbachia through an urban population of Aedes aegypti.
Article in PLoS biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
134 citing papers in PubMed, 243 citations in OpenAlex.
- Advances in mosquito gut microbiota: Mechanisms of regulating pathogen transmission and applications in vector control.Virulence · 2026Review
- Horizons of the Future: Preparedness and Response.Current topics in microbiology and immunology · 2026Review
- The Diversity of Bacterial Symbionts in Major Agricultural Lepidopteran Pests in Australia.International journal of microbiology · 2026Article
- Improving Wolbachia-based control programs in urban settings: Insights from spatial modeling.PLoS neglected tropical diseases · 2025Article
- Article
- Ecological dynamics of field Aedes albopictus populations under Wolbachia-mediated suppression.Infectious diseases of poverty · 2025Article
- Reciprocal Host-Evolutionary applications · 2025Article
- Populations of the Australian Saltmarsh MosquitoEvolutionary applications · 2025Article
- ExploitingPathogens (Basel, Switzerland) · 2025Review
- Variable effects of transient Wolbachia infections on alphaviruses in Aedes aegypti.PLoS neglected tropical diseases · 2024Article
- Considerations for first field trials of low-threshold gene drive for malaria vector control.Malaria journal · 2024Review
- Reanalysis of cluster randomised trial data to account for exposure misclassification using a per-protocol and complier-restricted approach.Scientific reports · 2024Article
- First report of natural infection of Anopheles gambiae s.s. and Anopheles coluzzii by Wolbachia and Microsporidia in Benin: a cross-sectional study.Malaria journal · 2024Article
- Controlling arbovirus infection: high-throughput transcriptome and proteome insights.Frontiers in microbiology · 2024Review
- Measuring Host Fitness Effects and Transmission of Wolbachia Strains in Aedes aegypti Mosquitoes.Methods in molecular biology (Clifton, N.J.) · 2024Article
- [Rapid review: effectiveness of theRevista panamericana de salud publica = Pan American journal of public health · 2024Article
- Limited association betweenEvolutionary applications · 2023Article
- Large-scale releases and establishment of wMel Wolbachia in Aedes aegypti mosquitoes throughout the Cities of Bello, Medellín and Itagüí, Colombia.PLoS neglected tropical diseases · 2023Article
- The double-edged sword effect of expandingLancet regional health. Americas · 2023Article
- Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
Dengue-suppressing Wolbachia strains are promising tools for arbovirus control, particularly as they have the potential to self-spread following local introductions. To test this, we followed the frequency of the transinfected Wolbachia strain wMel through Ae. aegypti in Cairns, Australia, following releases at 3 nonisolated locations within the city in early 2013. Spatial spread was analysed graphically using interpolation and by fitting a statistical model describing the position and width of the wave. For the larger 2 of the 3 releases (covering 0.97 km2 and 0.52 km2), we observed slow but steady spatial spread, at about 100-200 m per year, roughly consistent with theoretical predictions. In contrast, the smallest release (0.11 km2) produced erratic temporal and spatial dynamics, with little evidence of spread after 2 years. This is consistent with the prediction concerning fitness-decreasing Wolbachia transinfections that a minimum release area is needed to achieve stable local establishment and spread in continuous habitats. Our graphical and likelihood analyses produced broadly consistent estimates of wave speed and wave width. Spread at all sites was spatially heterogeneous, suggesting that environmental heterogeneity will affect large-scale Wolbachia transformations of urban mosquito populations. The persistence and spread of Wolbachia in release areas meeting minimum area requirements indicates the promise of successful large-scale population transformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.